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The Journal of Neuroscience, April 30, 2008, 28(18):4726-4735; doi:10.1523/JNEUROSCI.0057-08.2008

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Behavioral/Systems/Cognitive
Perceptuo-Motor Interactions during Prehension Movements

Lennart Verhagen,^1,2 H. Chris Dijkerman,² Meike J. Grol,^1,2,3,4,5 and Ivan Toni^1,6

¹F. C. Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6500 HB, Nijmegen, The Netherlands, ²Experimental Psychology, Helmholtz Institute, Utrecht University, 3508 TC, Utrecht, The Netherlands, ³Leiden Institute for Brain and Cognition, ⁴Institute for Psychological Research, and ⁵Department of Radiology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands, and ⁶Nijmegen Institute for Cognition and Information, Radboud University Nijmegen, 6500 HE, Nijmegen, The Netherlands

Correspondence should be addressed to Lennart Verhagen, Helmholtz Institute, Utrecht University, Heidelberglaan 2, 3584 CS, P.O. Box 80125, 3508 TC Utrecht, The Netherlands. Email: l.verhagen{at}uu.nl

Adaptive behavior relies on the integration of perceptual and motor processes. In this study, we aimed at characterizing the cerebral processes underlying perceptuo-motor interactions evoked during prehension movements in healthy humans, as measured by means of functional magnetic resonance imaging. We manipulated the viewing conditions (binocular or monocular) during planning of a prehension movement, while parametrically varying the slant of the grasped object. This design manipulates the relative relevance and availability of different depth cues necessary for accurate planning of the prehension movement, biasing visual information processing toward either the dorsal visual stream (binocular vision) or the ventral visual stream (monocular vision). Two critical nodes of the dorsomedial visuomotor stream [V6A (anterior visual area 6) and PMd (dorsal premotor cortex)] increased their activity with increasing object slant, regardless of viewing conditions. In contrast, areas in both the dorsolateral visuomotor stream [anterior intraparietal area (AIP) and ventral premotor cortex (PMv)] and in the ventral visual stream [lateral-occipital tactile-visual area (LOtv)] showed differential slant-related responses, with activity increasing when monocular viewing conditions and increasing slant required the processing of pictorial depth cues. These conditions also increased the functional coupling of AIP with both LOtv and PMv. These findings support the view that the dorsomedial stream is automatically involved in processing visuospatial parameters for grasping, regardless of viewing conditions or object characteristics. In contrast, the dorsolateral stream appears to adapt motor behavior to the current conditions by integrating perceptual information processed in the ventral stream into the prehension plan.

Key words: grasping; ventral visual stream; dorsomedial visuomotor stream; dorsolateral visuomotor stream; lateral occipital complex; anterior intraparietal area

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Received Jan. 7, 2008; revised March 28, 2008; accepted March 31, 2008.

Correspondence should be addressed to Lennart Verhagen, Helmholtz Institute, Utrecht University, Heidelberglaan 2, 3584 CS, P.O. Box 80125, 3508 TC Utrecht, The Netherlands. Email: l.verhagen{at}uu.nl

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