 |
||||
|
||||
|
||||
|
||||
|
||||
The Journal of Neuroscience, May 21, 2008, 28(21):5513-5518; doi:10.1523/JNEUROSCI.5374-07.2008
This Article Full Text Full Text (PDF) Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager 
Citing Articles Citing Articles via Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Gais, S. Articles by Born, J. Search for Related Content PubMed PubMed Citation Articles by Gais, S. Articles by Born, J. Pubmed/NCBI databases
Compound via MeSH
Hazardous Substances DB Medline Plus Health Information
Previous Article | Next Article
Behavioral/Systems/Cognitive
Visual–Procedural Memory Consolidation during Sleep Blocked by Glutamatergic Receptor Antagonists
Steffen Gais, Björn Rasch, Ullrich Wagner, andJan Born Department of Neuroendocrinology, University of Lübeck, 23538 Lübeck, Germany
Correspondence should be addressed to either Jan Born or Steffen Gais, Department of Neuroendocrinology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. Email: born{at}kfg.uni-luebeck.de or Email: gais{at}kfg.uni-luebeck.de
Visual cortex plasticity is enhanced by sleep. It is hypothesized that a reactivation of glutamatergic synapses is essential for this form of plasticity to occur after learning. To test this hypothesis, human subjects practiced a visual texture discrimination skill known to require post-training sleep for improvements to occur. During sleep, glutamatergic transmission was inhibited by administration of the two glutamate antagonists, caroverine and ketamine, targeting the ionotropic NMDA and AMPA receptors. Both substances given during consolidation sleep in a placebo controlled crossover design were able to prevent improvement of the skill measured the next morning. An off-line activation of glutamatergic synapses therefore seems to play a critical part in the consolidation of plastic changes in the visual cortex.
Key words: sleep; memory consolidation; skill learning; visual discrimination; glutamate receptor; human
Received Dec. 5, 2007; revised March 11, 2008; accepted April 4, 2008.
Correspondence should be addressed to either Jan Born or Steffen Gais, Department of Neuroendocrinology, University of Lübeck, Ratzeburger Allee 160, 23538 Lübeck, Germany. Email: born{at}kfg.uni-luebeck.de or Email: gais{at}kfg.uni-luebeck.de
|
|
|
|
 |
|