QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, May 21, 2008, 28(21):5539-5546; doi:10.1523/JNEUROSCI.5290-07.2008

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Google Scholar Articles by Liu, T. Articles by Guo, A. PubMed PubMed Citation Articles by Liu, T. Articles by Guo, A. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB DOPAMINE

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Increased Dopamine Level Enhances Male–Male Courtship in Drosophila

Tong Liu,^1,2 Laurence Dartevelle,⁴ Chunyan Yuan,¹ Hongping Wei,^1,2 Ying Wang,¹ Jean-François Ferveur,⁴ and Aike Guo^1,3

¹Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China, ²Graduate School of Chinese Academy of Sciences, Beijing 100039, China, ³State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, and ⁴Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5548, Universite de Bourgogne, Dijon 21000, France

Correspondence should be addressed to either of the following: Aike Guo, Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China, Email: akguo{at}ion.ac.cn; or Jean-François Ferveur, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5548, Universite de Bourgogne, Dijon 21000, France, E-mail: Email: jean-francois.ferveur{at}u-bourgogne.fr

Sexual behavior between males is observed in many species, but the biological factors involved are poorly known. In mammals, manipulation of dopamine has revealed the role of this neuromodulator on male sexual behavior. We used genetic and pharmacological approaches to manipulate the dopamine level in dopaminergic cells in Drosophila and investigated the consequence of this manipulation on male–male courtship behavior. Males with increased dopamine level showed enhanced propensity to court other males but did not change their courtship toward virgin females, general olfactory response, general gustatory response, or locomotor activity. Our results indicate that the high intensity of male–male interaction shown by these manipulated males was related to their altered sensory perception of other males.

Key words: Drosophila; courtship; male–male courtship behavior; neurotransmitter; tyrosine hydroxylase; dopamine

---

Received Sept. 3, 2007; revised March 9, 2008; accepted April 14, 2008.

Correspondence should be addressed to either of the following: Aike Guo, Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China, Email: akguo{at}ion.ac.cn; or Jean-François Ferveur, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5548, Universite de Bourgogne, Dijon 21000, France, E-mail: Email: jean-francois.ferveur{at}u-bourgogne.fr

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help