QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, June 4, 2008, 28(23):5944-5953; doi:10.1523/JNEUROSCI.0957-08.2008

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (4) Citing Articles via Google Scholar Google Scholar Articles by Koch, G. Articles by Rothwell, J. C. Search for Related Content PubMed PubMed Citation Articles by Koch, G. Articles by Rothwell, J. C.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Functional Interplay between Posterior Parietal and Ipsilateral Motor Cortex Revealed by Twin-Coil Transcranial Magnetic Stimulation during Reach Planning toward Contralateral Space

Giacomo Koch,^1,2,3 Miguel Fernandez Del Olmo,^1,4 Binith Cheeran,¹ Sven Schippling,¹ Carlo Caltagirone,^2,3 Jon Driver,^5,6 and John C. Rothwell¹

¹Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, London WC1N 3BG, United Kingdom, ²Laboratorio di Neurologia Clinica e Comportamentale, Fondazione Santa Lucia, Instituto di Ricovero e Cura a Carattere Scientifico, 00179 Rome, Italy, ³Clinica Neurologica, Dipartimento di Neuroscienze, Università di Roma Tor Vergata, 00133 Rome, Italy, ⁴Instituto Nacional de Educación Física, Galicia, 15179 La Coruña, Spain, and ⁵Institute of Cognitive Neuroscience and ⁶Department of Psychology, University College London, London WC1N 3AR, United Kingdom

Correspondence should be addressed to Prof. John C. Rothwell, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK. Email: j.rothwell{at}ion.ucl.ac.uk

Posterior parietal cortex (PPC) has connections with motor and premotor cortex, thought to transfer information relevant for planning movements in space. We used twin-coil transcranial magnetic stimulation (tcTMS) methods to show that the functional interplay between human right PPC and ipsilateral motor cortex (M1) varies with current motor plans. tcTMS during the reaction time of a reach task revealed facilitatory influences of right PPC on right M1 only when planning a (contralateral) leftward rather than rightward reach, at two specific time intervals (50 and 125 ms) after an auditory cue. The earlier reach-direction-specific facilitatory influence from PPC on M1 occurred when subjects were blindfolded or when the targets were presented briefly, so that visual feedback corrections could not occur. PPC–M1 interplay was similar within the left hemisphere but was specific to (contralateral) rightward planned reaches, with peaks at 50 and 100 ms. Functional interplay between human parietal and motor cortex is enhanced during early stages of planning a reach in the contralateral direction.

Key words: transcranial magnetic stimulation; connectivity; reaching; parietal cortex; motor control; motor-evoked potential

---

Received Dec. 19, 2007; revised April 5, 2008; accepted April 8, 2008.

Correspondence should be addressed to Prof. John C. Rothwell, Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, UCL, Queen Square, London WC1N 3BG, UK. Email: j.rothwell{at}ion.ucl.ac.uk

This article has been cited by other articles:

				G. Koch, D. Ruge, B. Cheeran, M. Fernandez Del Olmo, C. Pecchioli, B. Marconi, V. Versace, E. Lo Gerfo, S. Torriero, M. Oliveri, et al. TMS activation of interhemispheric pathways between the posterior parietal cortex and the contralateral motor cortex J. Physiol., September 1, 2009; 587(17): 4281 - 4292. [Abstract] [Full Text] [PDF]

				G. Koch, M. Oliveri, B. Cheeran, D. Ruge, E. L. Gerfo, S. Salerno, S. Torriero, B. Marconi, F. Mori, J. Driver, et al. Hyperexcitability of parietal-motor functional connections in the intact left-hemisphere of patients with neglect Brain, December 1, 2008; 131(12): 3147 - 3155. [Abstract] [Full Text] [PDF]

				M. Vesia, X. Yan, D. Y. Henriques, L. E. Sergio, and J. D. Crawford Transcranial Magnetic Stimulation Over Human Dorsal-Lateral Posterior Parietal Cortex Disrupts Integration of Hand Position Signals Into the Reach Plan J Neurophysiol, October 1, 2008; 100(4): 2005 - 2014. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help