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The Journal of Neuroscience, June 18, 2008, 28(25):6372-6382; doi:10.1523/JNEUROSCI.1054-08.2008

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Behavioral/Systems/Cognitive
Preferential Reactivation of Motivationally Relevant Information in the Ventral Striatum

Carien S. Lansink,1 Pieter M. Goltstein,1 Jan V. Lankelma,1 Ruud N. J. M. A. Joosten,1,2 Bruce L. McNaughton,3 and Cyriel M. A. Pennartz1

1Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, 1090 GB Amsterdam, The Netherlands, 2Netherlands Institute for Neurosciences, 1105 BA Amsterdam, The Netherlands, and 3Division of Neural Systems, Memory, and Aging, Arizona Research Laboratories, University of Arizona, Tucson, Arizona 85724

Correspondence should be addressed to Cyriel M. A. Pennartz, Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, P.O. Box 94084, 1090 GB Amsterdam, The Netherlands. Email: pennartz{at}science.uva.nl

Spontaneous "off-line" reactivation of neuronal activity patterns may contribute to the consolidation of memory traces. The ventral striatum exhibits reactivation and has been implicated in the processing of motivational information. It is unknown, however, whether reactivating neuronal ensembles specifically recapitulate information relating to rewards that were encountered during wakefulness. We demonstrate a prolonged reactivation in rat ventral striatum during quiet wakefulness and slow-wave but not rapid eye movement sleep. Reactivation of reward-related information processed in this structure was particularly prominent, and this was primarily attributable to spike trains temporally linked to reward sites. It was accounted for by small, strongly correlated subgroups in recorded cell assemblies and can thus be characterized as a sparse phenomenon. Our results indicate that reactivated memory traces may not only comprise feature- and context-specific information but also contain a value component.

Key words: nucleus accumbens; learning; memory consolidation; reinforcer; reward; tetrodes

Received Nov. 1, 2007; revised April 28, 2008; accepted May 12, 2008.

Correspondence should be addressed to Cyriel M. A. Pennartz, Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, P.O. Box 94084, 1090 GB Amsterdam, The Netherlands. Email: pennartz{at}science.uva.nl






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