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The Journal of Neuroscience, June 18, 2008, 28(25):6453-6458; doi:10.1523/JNEUROSCI.0573-08.2008

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Brief Communications
Loss of Resting Interhemispheric Functional Connectivity after Complete Section of the Corpus Callosum

James M. Johnston,¹ S. Neil Vaishnavi,² Matthew D. Smyth,¹ Dongyang Zhang,² Biyu J. He,² John M. Zempel,³ Joshua S. Shimony,² Abraham Z. Snyder,^2,3 and Marcus E. Raichle^2,3,4,5

¹Departments of Neurosurgery, ²Radiology, ³Neurology, ⁴Neurobiology, and ⁵Biomedical Engineering, Washington University, St. Louis, Missouri 63110

Correspondence should be addressed to James M. Johnston, Department of Neurosurgery, Washington University School of Medicine, Campus Box 8225, 4525 Scott Avenue, East Building, St. Louis, MO 63110. Email: johnstonj{at}nsurg.wustl.edu

Slow (<0.1 Hz), spontaneous fluctuations in the functional magnetic resonance imaging blood oxygen level-dependent (BOLD) signal have been shown to exhibit phase coherence within functionally related areas of the brain. Surprisingly, this phenomenon appears to transcend levels of consciousness. The genesis of coherent BOLD fluctuations remains to be fully explained. We present a resting state functional connectivity study of a 6-year-old child with a radiologically normal brain imaged both before and after complete section of the corpus callosum for the treatment of intractable epilepsy. Postoperatively, there was a striking loss of interhemispheric BOLD correlations with preserved intrahemispheric correlations. These unique data provide important insights into the relationship between connectional anatomy and functional organization of the human brain. Such observations have the potential to increase our understanding of large-scale brain systems in health and disease as well as improve the treatment of neurologic disorders.

Key words: synchrony; functional connectivity; corpus callosotomy; epilepsy; fMRI; resting state

---

Received Feb. 7, 2008; revised May 7, 2008; accepted May 13, 2008.

Correspondence should be addressed to James M. Johnston, Department of Neurosurgery, Washington University School of Medicine, Campus Box 8225, 4525 Scott Avenue, East Building, St. Louis, MO 63110. Email: johnstonj{at}nsurg.wustl.edu

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Interhemispheric resting-state functional connectivity: insights from the split-brain

Lucina Q. Uddin

J. Neurosci. Online, 26 Jun 2008 [Full text]

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