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The Journal of Neuroscience, July 2, 2008, 28(27):6807-6817; doi:10.1523/JNEUROSCI.4206-07.2008

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Behavioral/Systems/Cognitive
A Retinal Circuit That Computes Object Motion

Stephen A. Baccus,1,2 Bence P. Ölveczky,1 Mihai Manu,2 and Markus Meister1

1Department of Molecular and Cellular Biology and Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138, and 2Department of Neurobiology, Stanford University School of Medicine, Stanford, California 94305

Correspondence should be addressed to Stephen A. Baccus, Department of Neurobiology, Stanford University School of Medicine, 299 West Campus Drive, Stanford, CA 94305. Email: baccus{at}stanford.edu

Certain ganglion cells in the retina respond sensitively to differential motion between the receptive field center and surround, as produced by an object moving over the background, but are strongly suppressed by global image motion, as produced by the observer's head or eye movements. We investigated the circuit basis for this object motion sensitive (OMS) response by recording intracellularly from all classes of retinal interneurons while simultaneously recording the spiking output of many ganglion cells. Fast, transient bipolar cells respond linearly to motion in the receptive field center. The synaptic output from their terminals is rectified and then pooled by the OMS ganglion cell. A type of polyaxonal amacrine cell is driven by motion in the surround, again via pooling of rectified inputs, but from a different set of bipolar cell terminals. By direct intracellular current injection, we found that these polyaxonal amacrine cells selectively suppress the synaptic input of OMS ganglion cells. A quantitative model of these circuit elements and their interactions explains how an important visual computation is accomplished by retinal neurons and synapses.

Key words: neural coding; eye movements; motion processing; computational model; neural circuit; inhibition

Received Sept. 13, 2007; revised April 1, 2008; accepted April 24, 2008.

Correspondence should be addressed to Stephen A. Baccus, Department of Neurobiology, Stanford University School of Medicine, 299 West Campus Drive, Stanford, CA 94305. Email: baccus{at}stanford.edu






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