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The Journal of Neuroscience, September 10, 2008, 28(37):9227-9238; doi:10.1523/JNEUROSCI.1576-08.2008

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Behavioral/Systems/Cognitive
Behavioral State Regulation of Dendrodendritic Synaptic Inhibition in the Olfactory Bulb

Yusuke Tsuno, Hideki Kashiwadani, and Kensaku Mori

Department of Physiology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan

Correspondence should be addressed to Dr. Kensaku Mori, Department of Physiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Email: moriken{at}m.u-tokyo.ac.jp

Behavioral states regulate how information is processed in local neuronal circuits. Here, we asked whether dendrodendritic synaptic interactions in the olfactory bulb vary with brain and behavioral states. To examine the state-dependent change of the dendrodendritic synaptic transmission, we monitored changes in field potential responses in the olfactory bulb of urethane-anesthetized and freely behaving rats. In urethane-anesthetized rats, granule-to-mitral dendrodendritic synaptic inhibition was larger and longer when slow waves were present in the electroencephalogram (slow-wave state) than during the fast-wave state. The state-dependent alternating change in the granule-to-mitral inhibition was regulated by the cholinergic system. In addition, the frequency of the spontaneous oscillatory activity of local field potentials and periodic discharges of mitral cells in the olfactory bulb shifted in synchrony with shifts in the neocortical brain state. Freely behaving rats showed multilevel changes in dendrodendritic synaptic inhibition that corresponded to diverse behavioral states; the inhibition was the largest during slow-wave sleep state, and successively smaller during light sleep, awake immobility, and awake moving states. These results provide evidence that behavioral state-dependent global changes in cholinergic tone modulate dendrodendritic synaptic inhibition and the information processing mode in the olfactory bulb.

Key words: dendrodendritic synapses; state; olfactory bulb; cholinergic; sleep; evoked field potential

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Received April 10, 2008; revised Aug. 3, 2008; accepted Aug. 3, 2008.

Correspondence should be addressed to Dr. Kensaku Mori, Department of Physiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Email: moriken{at}m.u-tokyo.ac.jp

This article has been cited by other articles:

				A. S. Ghatpande and A. Gelperin Presynaptic Muscarinic Receptors Enhance Glutamate Release at the Mitral/Tufted to Granule Cell Dendrodendritic Synapse in the Rat Main Olfactory Bulb J Neurophysiol, April 1, 2009; 101(4): 2052 - 2061. [Abstract] [Full Text] [PDF]

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