QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, September 17, 2008, 28(38):9414-9425; doi:10.1523/JNEUROSCI.3196-08.2008

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (1) Citing Articles via Google Scholar Google Scholar Articles by Giocomo, L. M. Articles by Hasselmo, M. E. Search for Related Content PubMed PubMed Citation Articles by Giocomo, L. M. Articles by Hasselmo, M. E.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Time Constants of h Current in Layer II Stellate Cells Differ along the Dorsal to Ventral Axis of Medial Entorhinal Cortex

Lisa M. Giocomo and Michael E. Hasselmo

Center for Memory and Brain, Program in Neuroscience and Department of Psychology, Boston University, Boston, Massachusetts 02215

Correspondence should be addressed to Lisa M. Giocomo, Center for Memory and Brain, Program in Neuroscience and Department of Psychology, Boston University, 2 Cummington Street, Boston, MA 02215. Email: giocomo{at}gmail.com

Chronic recordings in the medial entorhinal cortex of behaving rats have found grid cells, neurons that fire when the rat is in a hexagonal array of locations. Grid cells recorded at different dorsal–ventral anatomical positions show systematic changes in size and spacing of firing fields. To test possible mechanisms underlying these differences, we analyzed properties of the hyperpolarization-activated cation current I_h in voltage-clamp recordings from stellate cells in entorhinal slices from different dorsal–ventral locations. The time constant of h current was significantly different between dorsal and ventral neurons. The time constant of h current correlated with membrane potential oscillation frequency and the time constant of the sag potential in the same neurons. Differences in h current could underlie differences in membrane potential oscillation properties and contribute to grid cell periodicity along the dorsal–ventral axis of medial entorhinal cortex.

Key words: h current; grid cells; entorhinal cortex; stellate cells; subthreshold oscillations; HCN subunit

---

Received July 9, 2008; accepted Aug. 11, 2008.

Correspondence should be addressed to Lisa M. Giocomo, Center for Memory and Brain, Program in Neuroscience and Department of Psychology, Boston University, 2 Cummington Street, Boston, MA 02215. Email: giocomo{at}gmail.com

This article has been cited by other articles:

				L. M. Giocomo and M. E. Hasselmo Knock-Out of HCN1 Subunit Flattens Dorsal-Ventral Frequency Gradient of Medial Entorhinal Neurons in Adult Mice J. Neurosci., June 10, 2009; 29(23): 7625 - 7630. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help