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The Journal of Neuroscience, October 8, 2008, 28(41):10287-10297; doi:10.1523/JNEUROSCI.2372-08.2008

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Behavioral/Systems/Cognitive
Transformation of a Virtual Action Plan into a Motor Plan in the Premotor Cortex

Yoshihisa Nakayama, Tomoko Yamagata, Jun Tanji, and Eiji Hoshi

Tamagawa University Brain Science Institute, Tokyo 194-8610, Japan

Correspondence should be addressed to Dr. Eiji Hoshi, Tamagawa University Brain Science Institute, Tamagawa Gakuen 6-1-1, Machida, Tokyo 194-8610, Japan. Email: hoshie{at}lab.tamagawa.ac.jp

Before preparing to initiate a forthcoming motion, we often acquire information about the future action without specifying actual motor parameters. The information for planning an action at this conceptual level can be provided with verbal commands or nonverbal signals even before the associated motor targets are visible. Under these conditions, the information signifying a virtual action plan must be transformed to information that can be used for constructing a motor plan to initiate specific movements. To determine whether the premotor cortex is involved in this process, we examined neuronal activity in the dorsal premotor cortex (PMd) of monkeys performing a behavioral task designed to isolate the behavioral stages of the acquisition of information for a future action and the construction of a motor plan. We trained the animals to receive a symbolic instruction (color and shape of an instruction cue) to determine whether to select the right or left of targets to reach, despite the physical absence of targets. Subsequently, two targets appeared on a screen at different locations. The animals then determined the correct target (left or right) based on the previous instruction and prepared to initiate a reaching movement to an actual target. The experimental design dissociated the selection of the right/left at an abstract level (action plan) from the physical motor plan. Here, we show that activity of individual PMd neurons initially reflects a virtual action plan transcending motor specifics, before these neurons contribute to a transformation process that leads to activity encoding a motor plan.

Key words: premotor; frontal; motor cortex; motor control; sensorimotor; macaque

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Received May 25, 2008; revised Aug. 21, 2008; accepted Aug. 25, 2008.

Correspondence should be addressed to Dr. Eiji Hoshi, Tamagawa University Brain Science Institute, Tamagawa Gakuen 6-1-1, Machida, Tokyo 194-8610, Japan. Email: hoshie{at}lab.tamagawa.ac.jp

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