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The Journal of Neuroscience, October 22, 2008, 28(43):10961-10971; doi:10.1523/JNEUROSCI.1956-08.2008
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Behavioral/Systems/Cognitive
Selectivity for Grasp in Local Field Potential and Single Neuron Activity Recorded Simultaneously from M1 and F5 in the Awake Macaque Monkey
Rachel L. Spinks,1 * Alexander Kraskov,1 * Thomas Brochier,2 M. Alessandra Umilta,3 andRoger N. Lemon1 1Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, London WC1N 3BG, United Kingdom, 2Institut de Neurosciences Cognitives de la Méditerranée, UMR 6193, Centre National de la Recherche Scientifique, 13402 Marseille, France, and 3Departmento di Neuroscienze, Sezione di Fisiologia, Universita' di Parma, 43100 Parma, Italy
Correspondence should be addressed to Dr. Roger N. Lemon, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK. Email: rlemon{at}ion.ucl.ac.uk
The selectivity for object-specific grasp in local field potentials (LFPs) was investigated in two awake macaque monkeys trained to observe, reach out, grasp and hold one of six objects presented in a pseudorandom order. Simultaneous, multiple electrode recordings were made from the hand representations of primary motor cortex (M1) and ventral premotor cortex (area F5). LFP activity was well developed during the observation and hold periods of the task, especially in the beta-frequency range (15–30 Hz). Selectivity of LFP activity for upcoming grasp was rare in the observation period, but common during stable grasp. The majority of M1 (90 of 92) and F5 (81of 97) sites showed selectivity for at least one frequency, which was maximal in the beta range but also present at higher frequencies (30–50 Hz). When the LFP power associated with grasp of a specific object was large in the beta-frequency range, it was usually of low power in the higher 30–50 Hz range, and vice-versa. Simple hook grips involving flexion of one or more fingers were associated with large beta power, whereas more complex grips involving the thumb (e.g., precision grip) were associated with small beta power. At many M1 sites, there was a highly significant inverse relationship between the tuning of spikes (including those of identified pyramidal tract neurons) and beta-range LFP for different grasps, whereas a positive correlation was found at higher frequencies (30–50 Hz). High levels of beta LFP and low pyramidal cell spike rate may reflect a common mechanism used to control motor set during different types of grasp.
Key words: macaque; motor cortex; premotor; visual motion; beta; gamma; spike trains
Received Aug. 22, 2008; accepted Sept. 15, 2008.
Correspondence should be addressed to Dr. Roger N. Lemon, Sobell Department of Motor Neuroscience and Movement Disorders, UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK. Email: rlemon{at}ion.ucl.ac.uk
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