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The Journal of Neuroscience, October 22, 2008, 28(43):11024-11029; doi:10.1523/JNEUROSCI.2429-08.2008

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Brief Communications
Schwann Cell to Axon Transfer of Ribosomes: Toward a Novel Understanding of the Role of Glia in the Nervous System

Felipe A. Court,¹ William T. J. Hendriks,^2,3 Harold D. MacGillavry,³ Jaime Alvarez,¹ and Jan van Minnen^3,4

¹Departamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica, 114-D Santiago, Chile, ²Laboratory for Neuroregeneration, Netherlands Institute for Neuroscience, an Institute of the Royal Academy of Arts and Sciences, 1105 BA, Amsterdam, the Netherlands, ³Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Faculty of Earth and Life Sciences, VU University, 1081 HV, Amsterdam, the Netherlands, and ⁴Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1

Correspondence should be addressed to either of the following: Felipe A. Court, Departamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica, 114-D Santiago, Chile, Email: fcourt{at}bio.puc.cl; or Jan van Minnen, Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1, Email: jvanminn{at}ucalgary.ca

Schwann cells play pivotal roles in the development and maintenance of the peripheral nervous system. Here, we show that intact sciatic nerve axons of mice contain a small population of ribosomes, which increases by several orders of magnitude when axons are desomatized (severed from their cell bodies). We furthermore demonstrate, using the Wallerian degeneration slow mouse as a model, that Schwann cells transfer polyribosomes to desomatized axons. These data indicate that Schwann cells have the propensity to control axonal protein synthesis by supplying ribosomes on local basis.

Key words: Schwann cell; ribosomes; Wallerian degeneration; axons; glia; intercellular transport

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Received May 23, 2008; revised Aug. 5, 2008; accepted Sept. 10, 2008.

Correspondence should be addressed to either of the following: Felipe A. Court, Departamento de Fisiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica, 114-D Santiago, Chile, Email: fcourt{at}bio.puc.cl; or Jan van Minnen, Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada T2N 4N1, Email: jvanminn{at}ucalgary.ca

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