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The Journal of Neuroscience, October 22, 2008, 28(43):11071-11078; doi:10.1523/JNEUROSCI.3263-08.2008

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Behavioral/Systems/Cognitive
Nigral Inhibition of GABAergic Neurons in Mouse Superior Colliculus

Katsuyuki Kaneda,^1,2 Kaoru Isa,^1,3 Yuchio Yanagawa,⁴ and Tadashi Isa^1,2,3

¹Department of Developmental Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444-8585, Japan, ²The Graduate University for Advanced Studies, Hayama, Kanagawa 240-0193, Japan, ³Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi, 332-0012, Japan, and ⁴Department of Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi, 371-8511, Japan

Correspondence should be addressed to Katsuyuki Kaneda, Department of Developmental Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444-8585, Japan. Email: kaneda{at}nips.ac.jp

The current dominant concept for the control of saccadic eye movements by the basal ganglia is that release from tonic GABAergic inhibition by the substantia nigra pars reticulata (SNr) triggers burst firings of intermediate gray layer (SGI) neurons in the superior colliculus (SC) to allow saccade initiation. This hypothesis is based on the assumption that SNr cells inhibit excitatory projection neurons in the SGI. Here we show that nigrotectal fibers are connected to local GABAergic neurons in the SGI with a similar frequency to non-GABAergic neurons. This was accomplished by applying neuroanatomical tracing and slice electrophysiological experiments in GAD67–green fluorescent protein (GFP) knock-in mice, in which GABAergic neurons specifically express GFP. We also found that GABA_A, but not GABA_B, receptors subserve nigrotectal transmission. The present results revealed a novel aspect on the role of the basal ganglia in the control of saccades, e.g., the SNr not only regulates burst initiation but also modulates the spatiotemporal properties of premotor neurons via connections to local GABAergic neurons in the SC.

Key words: superior colliculus; saccade; basal ganglia; substantia nigra pars reticulata; disinhibition; burst

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Received July 12, 2008; revised Aug. 20, 2008; accepted Sept. 9, 2008.

Correspondence should be addressed to Katsuyuki Kaneda, Department of Developmental Physiology, National Institute for Physiological Sciences, Myodaiji, Okazaki 444-8585, Japan. Email: kaneda{at}nips.ac.jp

This article has been cited by other articles:

				T. Isa and W. C. Hall Exploring the Superior Colliculus In Vitro J Neurophysiol, November 1, 2009; 102(5): 2581 - 2593. [Abstract] [Full Text] [PDF]

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