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The Journal of Neuroscience, October 29, 2008, 28(44):11186-11195; doi:10.1523/JNEUROSCI.1921-08.2008

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Cellular/Molecular
Firing-Pattern-Dependent Specificity of Cortical Excitatory Feed-Forward Subnetworks

Takeshi Otsuka and Yasuo Kawaguchi

Division of Cerebral Circuitry, National Institute for Physiological Sciences, Okazaki, Aichi 444-8787, Japan

Correspondence should be addressed to Yasuo Kawaguchi, Division of Cerebral Circuitry, National Institute for Physiological Sciences, 5-1 Myodaiji-Higashiyama, Okazaki, Aichi 444-8787, Japan. Email: yasuo{at}nips.ac.jp

The cortical circuit includes networks of highly interconnected pyramidal neurons. Here, we investigated whether pyramidal cells form subnetworks depending on pyramidal subtypes. We classified layer V (L5) pyramidal cells in rat frontal cortex into three physiological subtypes based on the presence (SA-d type) or absence (SA type) of an initial burst in neurons displaying slowly adapting spike trains, or fast spike frequency adaptation (FA type) against current pulse injections. Pyramidal cells projecting to the particular subcortical areas were correlated with the physiological subtypes. Focal glutamate stimulation of a L2/3 pyramidal cell induced EPSCs in SA and SA-d cells more frequently than in FA cells. FA cells in upper L5 received more inputs from the upper L2/3, and those in lower L5 received inputs from cells in lower L2/3, suggesting topographic interlaminar projections to FA cells. Dual recordings from L5 pyramidal cells revealed that common input probability that two L5 cells share inputs from a L2/3 cell was high in cell pairs of the same subtypes, compared with those in different subtype pairs. Furthermore, the common input probability was highly selective when cell pairs of the same subtypes, but not different subtypes, had connections between them. Our results suggest that L2/3 pyramidal cells selectively innervate L5 cells, depending on their firing subtypes.

Key words: cortex; pyramidal cell; firing pattern; extracortical projection; connection specificity; interlaminar connection

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Received Sept. 8, 2008; accepted Sept. 20, 2008.

Correspondence should be addressed to Yasuo Kawaguchi, Division of Cerebral Circuitry, National Institute for Physiological Sciences, 5-1 Myodaiji-Higashiyama, Okazaki, Aichi 444-8787, Japan. Email: yasuo{at}nips.ac.jp

This article has been cited by other articles:

				T. Otsuka and Y. Kawaguchi Cortical Inhibitory Cell Types Differentially Form Intralaminar and Interlaminar Subnetworks withExcitatory Neurons J. Neurosci., August 26, 2009; 29(34): 10533 - 10540. [Abstract] [Full Text] [PDF]

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