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The Journal of Neuroscience, November 12, 2008, 28(46):11746-11752; doi:10.1523/JNEUROSCI.3860-08.2008

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Symposia and Mini-Symposia
Modes and Mishaps of Neuronal Migration in the Mammalian Brain

Christine Métin,¹ Richard B. Vallee,² Pasko Rakic,³ and Pradeep G. Bhide⁴

¹Institut du Fer à Moulin, Inserm Unité Mixte de Recherche-S 839, 75005 Paris, France, ²Department of Pathology, Columbia University, New York, New York 10032, ³Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520-8001, and ⁴Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129

Correspondence should be addressed to Dr. Pradeep G. Bhide, Developmental Neurobiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129. Email: bhide{at}helix.mgh.harvard.edu

The ability of neurons to migrate to their appropriate positions in the developing brain is critical to brain architecture and function. Recent research has elucidated different modes of neuronal migration and the involvement of a host of signaling factors in orchestrating the migration, as well as vulnerabilities of this process to environmental and genetic factors. Here we discuss the role of cytoskeleton, motor proteins, and mechanisms of nuclear translocation in radial and tangential migration of neurons. We will also discuss how these and other events essential for normal migration of neurons can be disrupted by genetic and environmental factors that contribute to neurological disease in humans.

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Received Aug. 8, 2008; revised Aug. 29, 2008; accepted Sept. 3, 2008.

Correspondence should be addressed to Dr. Pradeep G. Bhide, Developmental Neurobiology, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129. Email: bhide{at}helix.mgh.harvard.edu

This article has been cited by other articles:

				K. Letinic, R. Sebastian, D. Toomre, and P. Rakic Exocyst is involved in polarized cell migration and cerebral cortical development PNAS, July 7, 2009; 106(27): 11342 - 11347. [Abstract] [Full Text] [PDF]

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