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The Journal of Neuroscience, November 12, 2008, 28(46):11753-11759; doi:10.1523/JNEUROSCI.3797-08.2008

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Symposia and Mini-Symposia
Epigenetics in the Nervous System

Yan Jiang,¹ Brett Langley,² Farah D. Lubin,³ William Renthal,⁴ Marcelo A. Wood,⁵ Dag H. Yasui,⁶ Arvind Kumar,⁴ Eric J. Nestler,⁴ Schahram Akbarian,¹ and Andrea C. Beckel-Mitchener⁷

¹Brudnick Neuropsychiatric Research Institute, University of Massachusetts Medical School, Worcester, Massachusetts 01604, ²Burke Medical Research Institute, Weill Medical College of Cornell University, White Plains, New York 10021, ³Department of Neurobiology, The Evelyn F. McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294-2182, ⁴Department of Psychiatry and Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, ⁵Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697-3800, ⁶Departments of Medical Microbiology and Immunology, Rowe Program in Human Genetics, School of Medicine, University of California, Davis, Davis, California 95616-8500, and ⁷National Institute of Mental Health–National Institutes of Health, Bethesda, Maryland 20892-9641

Correspondence should be addressed to Andrea C. Beckel-Mitchener, National Institute of Mental Health–National Institutes of Health, NSC, 6001 Executive Boulevard, Bethesda, MD 20892-9641. Email: amitchen{at}mail.nih.gov

It is becoming increasingly clear that epigenetic modifications are critical factors in the regulation of gene expression. With regard to the nervous system, epigenetic alterations play a role in a diverse set of processes and have been implicated in a variety of disorders. Gaining a more complete understanding of the essential components and underlying mechanisms involved in epigenetic regulation could lead to novel treatments for a number of neurological and psychiatric conditions.

Key words: epigenetics; chromatin; DNA methylation; histone; transcription; gene

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Received Aug. 1, 2008; revised Sept. 9, 2008; accepted Sept. 9, 2008.

Correspondence should be addressed to Andrea C. Beckel-Mitchener, National Institute of Mental Health–National Institutes of Health, NSC, 6001 Executive Boulevard, Bethesda, MD 20892-9641. Email: amitchen{at}mail.nih.gov

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