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The Journal of Neuroscience, November 12, 2008, 28(46):11825-11829; doi:10.1523/JNEUROSCI.3463-08.2008

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Symposia and Mini-Symposia
Habenula: Crossroad between the Basal Ganglia and the Limbic System

Okihide Hikosaka,¹ Susan R. Sesack,² Lucas Lecourtier,³ and Paul D. Shepard⁴

¹Laboratory of Sensorimotor Research, National Eye Institute–National Institutes of Health, Bethesda, Maryland 20892-4435, ²Departments of Neuroscience and Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, ³Laboratoire d'Imagerie et de Neurosciences Cognitives, Unité Mixte de Recherche 7191, Centre National de la Recherche Scientifique, Université Louis Pasteur, 67000 Strasbourg, France, and ⁴Department of Psychiatry, University of Maryland School of Medicine and Maryland Psychiatric Research Center, Baltimore, Maryland 21228

Correspondence should be addressed to Okihide Hikosaka, Laboratory of Sensorimotor Research, National Eye Institute–National Institutes of Health, Building 49, Room 2A50, 49 Convent Drive, Bethesda, MD 20892-4435. Email: oh{at}lsr.nei.nih.gov

There is a growing awareness that emotion, motivation, and reward values are important determinants of our behavior. The habenula is uniquely positioned both anatomically and functionally to participate in the circuit mediating some forms of emotive decision making. In the last few years there has been a surge of interest in this structure, especially the lateral habenula (LHb). The new studies suggest that the LHb plays a pivotal role in controlling motor and cognitive behaviors by influencing the activity of dopamine and serotonin neurons. Further, dysfunctions of the LHb have also been implicated in psychiatric disorders, such as depression, schizophrenia, and drug-induced psychosis.

Key words: reward; motivation; cognition; dopamine; striatum; serotonin; depression; schizophrenia

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Received July 23, 2008; revised Sept. 24, 2008; accepted Sept. 25, 2008.

Correspondence should be addressed to Okihide Hikosaka, Laboratory of Sensorimotor Research, National Eye Institute–National Institutes of Health, Building 49, Room 2A50, 49 Convent Drive, Bethesda, MD 20892-4435. Email: oh{at}lsr.nei.nih.gov

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