WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, November 26, 2008, 28(48):12815-12819; doi:10.1523/JNEUROSCI.2665-08.2008

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (2)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Park, J.
Right arrow Articles by Qiu, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Park, J.
Right arrow Articles by Qiu, M.

 Previous Article  |  Next Article 

Brief Communications
Disruption of Nectin-Like 1 Cell Adhesion Molecule Leads to Delayed Axonal Myelination in the CNS

Jinsil Park,2 * Ben Liu,1,2 * Tao Chen,1 Hong Li,2 Xuemei Hu,2 Jing Gao,1 Ying Zhu,2 Qiang Zhu,2 Boqin Qiang,1 Jiangang Yuan,1 Xiaozhong Peng,1 and Mengsheng Qiu2,3

1The National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China, 2Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, Kentucky 40292, and 3Institute of Urological Surgery, Tianjin Medical University, Tianjin 300211, China

Correspondence should be addressed to either of the following: Xiaozhong Peng, at the above address; Email: pengxiaozhong{at}pumc.edu.cn; or Mengsheng Qiu, at the above address; E-mail: Email: m0qiu001{at}louisville.edu

Nectin-like 1 (Necl-1) is a neural-specific cell adhesion molecule that is expressed in both the CNS and PNS. Previous in vitro studies suggested that Necl-1 expression is essential for the axon-glial interaction and myelin sheath formation in the PNS. To investigate the in vivo role of Necl-1 in axonal myelination of the developing nervous system, we generated the Necl-1 mutant mice by replacing axons 2–5 with the LacZ reporter gene. Expression studies revealed that Necl-1 is exclusively expressed by neurons in the CNS. Disruption of Necl-1 resulted in developmental delay of axonal myelination in the optic nerve and spinal cord, suggesting that Necl-1 plays an important role in the initial axon-oligodendrocyte recognition and adhesion in CNS myelination.

Key words: cell adhesion molecule; gene targeting; myelination; spinal cord; optic nerve; knock-out

Received June 10, 2008; revised Sept. 4, 2008; accepted Oct. 18, 2008.

Correspondence should be addressed to either of the following: Xiaozhong Peng, at the above address; Email: pengxiaozhong{at}pumc.edu.cn; or Mengsheng Qiu, at the above address; E-mail: Email: m0qiu001{at}louisville.edu




This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
H.-T. Chao and H. Y. Zoghbi
The yin and yang of MeCP2 phosphorylation
PNAS, March 24, 2009; 106(12): 4577 - 4578.
[Full Text] [PDF]


-
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-