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The Journal of Neuroscience, November 26, 2008, 28(48):12815-12819; doi:10.1523/JNEUROSCI.2665-08.2008

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Brief Communications
Disruption of Nectin-Like 1 Cell Adhesion Molecule Leads to Delayed Axonal Myelination in the CNS

Jinsil Park,^2 * Ben Liu,^1,2 * Tao Chen,¹ Hong Li,² Xuemei Hu,² Jing Gao,¹ Ying Zhu,² Qiang Zhu,² Boqin Qiang,¹ Jiangang Yuan,¹ Xiaozhong Peng,¹ and Mengsheng Qiu^2,3

¹The National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China, ²Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, Kentucky 40292, and ³Institute of Urological Surgery, Tianjin Medical University, Tianjin 300211, China

Correspondence should be addressed to either of the following: Xiaozhong Peng, at the above address; Email: pengxiaozhong{at}pumc.edu.cn; or Mengsheng Qiu, at the above address; E-mail: Email: m0qiu001{at}louisville.edu

Nectin-like 1 (Necl-1) is a neural-specific cell adhesion molecule that is expressed in both the CNS and PNS. Previous in vitro studies suggested that Necl-1 expression is essential for the axon-glial interaction and myelin sheath formation in the PNS. To investigate the in vivo role of Necl-1 in axonal myelination of the developing nervous system, we generated the Necl-1 mutant mice by replacing axons 2–5 with the LacZ reporter gene. Expression studies revealed that Necl-1 is exclusively expressed by neurons in the CNS. Disruption of Necl-1 resulted in developmental delay of axonal myelination in the optic nerve and spinal cord, suggesting that Necl-1 plays an important role in the initial axon-oligodendrocyte recognition and adhesion in CNS myelination.

Key words: cell adhesion molecule; gene targeting; myelination; spinal cord; optic nerve; knock-out

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Received June 10, 2008; revised Sept. 4, 2008; accepted Oct. 18, 2008.

Correspondence should be addressed to either of the following: Xiaozhong Peng, at the above address; Email: pengxiaozhong{at}pumc.edu.cn; or Mengsheng Qiu, at the above address; E-mail: Email: m0qiu001{at}louisville.edu

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