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The Journal of Neuroscience, November 26, 2008, 28(48):12864-12867; doi:10.1523/JNEUROSCI.2413-08.2008

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Brief Communications
Type 1 Adenylyl Cyclase Is Essential for Maintenance of Remote Contextual Fear Memory

Qiang Shan, Guy C.-K. Chan, and Daniel R. Storm

Department of Pharmacology, University of Washington, Seattle, Washington 98195

Correspondence should be addressed to Daniel R. Storm at the above address. Email: dstorm{at}u.washington.edu

Although molecular mechanisms for hippocampus-dependent memory have been extensively studied, much less is known about signaling events important for remote memory. Here we report that mice lacking type 1 adenylyl cyclase (AC1) are able to establish and retrieve remote contextual memory but unable to sustain it as long as wild-type mice. Interestingly, mice overexpressing AC1 show superior remote contextual memory even though they exhibit normal hippocampus-dependent contextual memory. These data illustrate that calcium coupling to cAMP contributes to the stability of remote memory and identifies AC1 as a potential drug target site to improve long-term remote memory.

Key words: calcium-sensitive adenylyl cyclase; anterior cingulate cortex; remote memory; contextual fear conditioning; memory maintenance; memory extinction

Received May 28, 2008; revised Sept. 9, 2008; accepted Oct. 11, 2008.

Correspondence should be addressed to Daniel R. Storm at the above address. Email: dstorm{at}u.washington.edu


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