QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, November 26, 2008, 28(48):12956-12968; doi:10.1523/JNEUROSCI.2890-08.2008

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Doischer, D. Articles by Bartos, M. Search for Related Content PubMed PubMed Citation Articles by Doischer, D. Articles by Bartos, M.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Postnatal Differentiation of Basket Cells from Slow to Fast Signaling Devices

Daniel Doischer,^1 * Jonas Aurel Hosp,^1 * Yuchio Yanagawa,³ Kunihiko Obata,⁴ Peter Jonas,¹ Imre Vida,^2,5 and Marlene Bartos^1,6

¹Physiologisches Institut I and ²Institut für Anatomie und Zellbiologie I, Universität Freiburg, D-79104 Freiburg, Germany, ³Department of Genetic and Behavioral Neuroscience, Gunma University, 371-8511 Maebashi, Gunma, Japan, ⁴Laboratory of Neurochemistry, National Institute for Physiological Sciences, 444-8585 Myodaiji, Okazaki, Japan, ⁵Division of Neuroscience and Biomedical Systems, Faculty of Biological Sciences, University of Glasgow, Glasgow G12 8QQ, United Kingdom, and ⁶Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, United Kingdom

Corresponding should be addressed to Dr. Marlene Bartos, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK. Email: m.bartos{at}abdn.ac.uk

Gamma frequency (30–100 Hz) oscillations in the mature cortex underlie higher cognitive functions. Fast signaling in GABAergic interneuron networks plays a key role in the generation of these oscillations. During development of the rodent brain, gamma activity appears at the end of the first postnatal week, but frequency and synchrony reach adult levels only by the fourth week. However, the mechanisms underlying the maturation of gamma activity are unclear. Here we demonstrate that hippocampal basket cells (BCs), the proposed cellular substrate of gamma oscillations, undergo marked changes in their morphological, intrinsic, and synaptic properties between postnatal day 6 (P6) and P25. During maturation, action potential duration, propagation time, duration of the release period, and decay time constant of IPSCs decreases by 30–60%. Thus, postnatal development converts BCs from slow into fast signaling devices. Computational analysis reveals that BC networks with young intrinsic and synaptic properties as well as reduced connectivity generate oscillations with moderate coherence in the lower gamma frequency range. In contrast, BC networks with mature properties and increased connectivity generate highly coherent activity in the upper gamma frequency band. Thus, late postnatal maturation of BCs enhances coherence in neuronal networks and will thereby contribute to the development of cognitive brain functions.

Key words: GABAergic neuron; development; dentate gyrus; basket cell; gamma; network

---

Received June 23, 2008; revised Sept. 28, 2008; accepted Oct. 16, 2008.

Corresponding should be addressed to Dr. Marlene Bartos, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK. Email: m.bartos{at}abdn.ac.uk

This article has been cited by other articles:

				J.-F. Sauer and M. Bartos Recruitment of Early Postnatal Parvalbumin-Positive Hippocampal Interneurons by GABAergic Excitation J. Neurosci., January 6, 2010; 30(1): 110 - 115. [Abstract] [Full Text] [PDF]

				P. Bonifazi, M. Goldin, M. A. Picardo, I. Jorquera, A. Cattani, G. Bianconi, A. Represa, Y. Ben-Ari, and R. Cossart GABAergic Hub Neurons Orchestrate Synchrony in Developing Hippocampal Networks Science, December 4, 2009; 326(5958): 1419 - 1424. [Abstract] [Full Text] [PDF]

				P. Li, U. Rudolph, and M. M. Huntsman Long-term sensory deprivation selectively rearranges functional inhibitory circuits in mouse barrel cortex PNAS, July 21, 2009; 106(29): 12156 - 12161. [Abstract] [Full Text] [PDF]

				B. W. Okaty, M. N. Miller, K. Sugino, C. M. Hempel, and S. B. Nelson Transcriptional and Electrophysiological Maturation of Neocortical Fast-Spiking GABAergic Interneurons J. Neurosci., May 27, 2009; 29(21): 7040 - 7052. [Abstract] [Full Text] [PDF]

				Z. J. Huang Activity-dependent development of inhibitory synapses and innervation pattern: role of GABA signalling and beyond J. Physiol., May 1, 2009; 587(9): 1881 - 1888. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help