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The Journal of Neuroscience, January 30, 2008, 28(5):1208-1212; doi:10.1523/JNEUROSCI.4475-07.2008

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Brief Communications
Working Memory Capacity Predicts Dopamine Synthesis Capacity in the Human Striatum

Roshan Cools,^1,2 * Sasha E. Gibbs,^1 * Asako Miyakawa,¹ William Jagust,^1,3 and Mark D'Esposito¹

¹Helen Wills Neuroscience Institute, University of California, Berkeley, California 94720-3190, ²F. C. Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6500 HB, Nijmegen, The Netherlands, and ³Lawrence Berkeley National Laboratory, Berkeley, California 94720

Correspondence should be addressed to Roshan Cools at the above address. Email: roshan.cools{at}fcdonders.ru.nl

Evidence from psychopharmacological research has revealed that dopamine receptor agents have opposite effects on cognitive function depending on baseline levels of working memory capacity. These contrasting effects have been interpreted to reflect differential baseline levels of dopamine. Here we demonstrate for the first time that working memory capacity as measured by listening span predicts dopamine synthesis capacity in the striatum, indicating that subjects with low working memory capacity have low DA synthesis capacity in the striatum, whereas subjects with high working memory capacity have high DA synthesis capacity in the striatum.

Key words: dopamine; working memory; striatum; listening span; PET; cognition; prefrontal cortex

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Received Oct. 1, 2007; revised Dec. 17, 2007; accepted Dec. 17, 2007.

Correspondence should be addressed to Roshan Cools at the above address. Email: roshan.cools{at}fcdonders.ru.nl

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