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The Journal of Neuroscience, December 17, 2008, 28(51):13738-13741; doi:10.1523/JNEUROSCI.3907-08.2008

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Brief Communications
Restoring Acid-Sensing Ion Channel-1a in the Amygdala of Knock-Out Mice Rescues Fear Memory But Not Unconditioned Fear Responses

Matthew W. Coryell,¹ Amanda M. Wunsch,² Jill M. Haenfler,^2,5 Jason E. Allen,² Jodi L. McBride,³ Beverly L. Davidson,^3,4 and John A. Wemmie^1,2,5

¹Neuroscience Program and Departments of ²Psychiatry, ³Internal Medicine, and ⁴Molecular Physiology and Biophysics, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, and ⁵Department of Veterans Affairs Medical Center, Iowa City, Iowa 52242

Correspondence should be addressed to Dr. John A. Wemmie, Department of Psychiatry, University of Iowa College of Medicine, 3139 Medical Laboratories, Iowa City, IA 52242. Email: john-wemmie{at}uiowa.edu

Acid-sensing ion channel-1a (ASIC1a) contributes to multiple fear behaviors, however the site of ASIC1a action in behavior is not known. To explore a specific location of ASIC1a action, we expressed ASIC1a in the basolateral amygdala of ASIC1a–/– mice using viral vector-mediated gene transfer. This rescued context-dependent fear memory, but not the freezing deficit during training or the unconditioned fear response to predator odor. These data pinpoint the basolateral amygdala as the site where ASIC1a contributes to fear memory. They also discriminate fear memory from fear expressed during training and from unconditioned fear. Furthermore, this work illustrates a strategy for identifying discrete brain regions where specific genes contribute to complex behaviors.

Key words: ASIC1a; region-restricted; viral-vector-mediated gene transfer; fear conditioning; unconditioned fear; amygdala

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Received Aug. 15, 2008; revised Oct. 31, 2008; accepted Oct. 31, 2008.

Correspondence should be addressed to Dr. John A. Wemmie, Department of Psychiatry, University of Iowa College of Medicine, 3139 Medical Laboratories, Iowa City, IA 52242. Email: john-wemmie{at}uiowa.edu

Related articles in J. Neurosci.:

Differential Involvement of ASIC1a in the Basolateral Amygdala in Fear Memory and Unconditioned Fear Responses

Stéphanie Grégoire and Julien Matricon
J. Neurosci. 2009 29: 6053-6054. [Full Text]  

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				T. W. Sherwood and C. C. Askwith Dynorphin Opioid Peptides Enhance Acid-Sensing Ion Channel 1a Activity and Acidosis-Induced Neuronal Death J. Neurosci., November 11, 2009; 29(45): 14371 - 14380. [Abstract] [Full Text] [PDF]

				S. Gregoire and J. Matricon Differential Involvement of ASIC1a in the Basolateral Amygdala in Fear Memory and Unconditioned Fear Responses J. Neurosci., May 13, 2009; 29(19): 6053 - 6054. [Full Text] [PDF]

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