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The Journal of Neuroscience, December 24, 2008, 28(52):14223-14229; doi:10.1523/JNEUROSCI.4271-08.2008

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Development/Plasticity/Repair
Prolonged Perceptual Learning of Positional Acuity in Adult Amblyopia: Perceptual Template Retuning Dynamics

Roger W Li,^1,2 Stanley A Klein,¹ and Dennis M Levi¹

¹School of Optometry and the Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, California 94720-2020, and ²Department of Psychology, The University of Hong Kong, Pokfulam, Hong Kong

Correspondence should be addressed to Roger Li, School of Optometry, University of California, Berkeley, Berkeley, CA 94720-2020. Email: oroger{at}berkeley.edu

Amblyopia is a developmental abnormality that results in physiological alterations in the visual cortex and impairs form vision. It is often successfully treated by patching the sound eye in infants and young children, but is generally considered to be untreatable in adults. However, a number of recent studies suggest that repetitive practice of a visual task using the amblyopic eye results in improved performance in both children and adults with amblyopia. These perceptual learning studies have used relatively brief periods of practice; however, clinical studies have shown that the time-constant for successful patching is long. The time-constant for perceptual learning in amblyopia is still unknown. Here we show that the time-constant for perceptual learning depends on the degree of amblyopia. Severe amblyopia requires >50 h (35,000 trials) to reach plateau, yielding as much as a five-fold improvement in performance at a rate of 1.5%/h. There is significant transfer of learning from the amblyopic to the dominant eye, suggesting that the learning reflects alterations in higher decision stages of processing. Using a reverse correlation technique, we document, for the first time, a dynamic retuning of the amblyopic perceptual decision template and a substantial reduction in internal spatial distortion. These results show that the mature amblyopic brain is surprisingly malleable, and point to more intensive treatment methods for amblyopia.

Key words: plasticity; critical period; visual learning; positional acuity; classification image; amblyopia

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Received Sept. 7, 2008; accepted Nov. 8, 2008.

Correspondence should be addressed to Roger Li, School of Optometry, University of California, Berkeley, Berkeley, CA 94720-2020. Email: oroger{at}berkeley.edu

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