QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, December 31, 2008, 28(53):14347-14357; doi:10.1523/JNEUROSCI.4307-08.2008

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Related articles in J. Neurosci. Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Devor, A. Articles by Boas, D. A. Search for Related Content PubMed PubMed Citation Articles by Devor, A. Articles by Boas, D. A.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Stimulus-Induced Changes in Blood Flow and 2-Deoxyglucose Uptake Dissociate in Ipsilateral Somatosensory Cortex

Anna Devor,^1,4,5 Elizabeth M. C. Hillman,¹ Peifang Tian,⁴ Christian Waeber,² Ivan C. Teng,⁴ Lana Ruvinskaya,¹ Mark H. Shalinsky,¹ Haihao Zhu,³ Robert H. Haslinger,¹ Suresh N. Narayanan,¹ Istvan Ulbert,^1,7,8 Andrew K. Dunn,⁹ Eng H. Lo,³ Bruce R. Rosen,¹ Anders M. Dale,^4,5 David Kleinfeld,⁶ and David A. Boas¹

¹Martinos Center for Biomedical Imaging, ²Stroke and Neurovascular Regulation Laboratory, and ³Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, Departments of ⁴Neurosciences, ⁵Radiology, and ⁶Physics, University of California, San Diego, La Jolla, California 92093, ⁷Institute for Psychology, Hungarian Academy of Sciences, Budapest 1068, Hungary, ⁸Department of Information Technology, Peter Pazmany Catholic University, Budapest 1083, Hungary, and ⁹Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712

Correspondence should be addressed to Anna Devor, Martinos Center for Biomedical Imaging, Building 149, 13th Street, Mailcode 149-2301, Charlestown, MA 02129. Email: adevor{at}nmr.mgh.harvard.edu

The present study addresses the relationship between blood flow and glucose consumption in rat primary somatosensory cortex (SI) in vivo. We examined bilateral neuronal and hemodynamic changes and 2-deoxyglucose (2DG) uptake, as measured by autoradiography, in response to unilateral forepaw stimulation. In contrast to the contralateral forepaw area, where neuronal activity, blood oxygenation/flow and 2DG uptake increased in unison, we observed, in the ipsilateral SI, a blood oxygenation/flow decrease and arteriolar vasoconstriction in the presence of increased 2DG uptake. Laminar electrophysiological recordings revealed an increase in ipsilateral spiking consistent with the observed increase in 2DG uptake. The vasoconstriction and the decrease in blood flow in the presence of an increase in 2DG uptake in the ipsilateral SI contradict the prominent metabolic hypothesis regarding the regulation of cerebral blood flow, which postulates that the state of neuroglial energy consumption determines the regional blood flow through the production of vasoactive metabolites. We propose that other factors, such as neuronal (and glial) release of messenger molecules, might play a dominant role in the regulation of blood flow in vivo in response to a physiological stimulus.

Key words: blood flow; cerebral cortex; corpus callosum; glucose consumption; inhibition; metabolism

---

Received Sept. 9, 2008; revised Nov. 11, 2008; accepted Nov. 13, 2008.

Correspondence should be addressed to Anna Devor, Martinos Center for Biomedical Imaging, Building 149, 13th Street, Mailcode 149-2301, Charlestown, MA 02129. Email: adevor{at}nmr.mgh.harvard.edu

Related articles in J. Neurosci.:

This Week in The Journal

J. Neurosci. 2008 28: i. [Full Text]  

This article has been cited by other articles:

				A. Nimmerjahn Astrocytes going live: advances and challenges J. Physiol., April 15, 2009; 587(8): 1639 - 1647. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help