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The Journal of Neuroscience, February 6, 2008, 28(6):1469-1478; doi:10.1523/JNEUROSCI.2723-07.2008

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Development/Plasticity/Repair
Cholinergic-Mediated IP₃-Receptor Activation Induces Long-Lasting Synaptic Enhancement in CA1 Pyramidal Neurons

David Fernández de Sevilla,¹ Angel Núñez,² Michel Borde,¹ Roberto Malinow,³ and Washington Buño¹

¹Instituto Cajal, Consejo Superior de Investigaciones Científicas, 28002 Madrid, Spain, ²Departamento de Anatomía, Histología y Neurociencia, Facultad de Medicina, Universidad Autónoma de Madrid, 28029 Madrid, Spain, and ³Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724

Correspondence should be addressed to David Fernández de Sevilla, Instituto Cajal, Consejo Superior de Investigaciones Científicas, Avenida Dr. Arce 37, 28002 Madrid, Spain. Email: desevilla{at}cajal.csic.es

Cholinergic–glutamatergic interactions influence forms of synaptic plasticity that are thought to mediate memory and learning. We tested in vitro the induction of long-lasting synaptic enhancement at Schaffer collaterals by acetylcholine (ACh) at the apical dendrite of CA1 pyramidal neurons and in vivo by stimulation of cholinergic afferents. In vitro ACh induced a Ca²⁺ wave and synaptic enhancement mediated by insertion of AMPA receptors in spines. Activation of muscarinic ACh receptors (mAChRs) and Ca²⁺ release from inositol 1,4,5-trisphosphate (IP₃)-sensitive stores were required for this synaptic enhancement that was insensitive to blockade of NMDA receptors and also triggered by IP₃ uncaging. Activation of cholinergic afferents in vivo induced an analogous atropine-sensitive synaptic enhancement. We describe a novel form of synaptic enhancement (LTP_IP3) that is induced in vitro and in vivo by activation of mAChRs. We conclude that Ca²⁺ released from postsynaptic endoplasmic reticulum stores is the critical event in the induction of this unique form of long-lasting synaptic enhancement.

Key words: LTP_IP3; endoplasmic reticulum; Ca²⁺ wave; AMPA trafficking; inositol; muscarinic

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Received June 15, 2007; revised Dec. 11, 2007; accepted Dec. 21, 2007.

Correspondence should be addressed to David Fernández de Sevilla, Instituto Cajal, Consejo Superior de Investigaciones Científicas, Avenida Dr. Arce 37, 28002 Madrid, Spain. Email: desevilla{at}cajal.csic.es

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