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The Journal of Neuroscience, February 20, 2008, 28(8):1929-1942; doi:10.1523/JNEUROSCI.3377-07.2008

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Behavioral/Systems/Cognitive
Nonlinearities and Contextual Influences in Auditory Cortical Responses Modeled with Multilinear Spectrotemporal Methods

Misha B. Ahrens,¹ Jennifer F. Linden,^2,3 and Maneesh Sahani¹

¹Gatsby Computational Neuroscience Unit, ²Department of Anatomy and Developmental Biology, and ³Ear Institute, University College London, London WC1N 3AR, United Kingdom

Correspondence should be addressed to Maneesh Sahani, Gatsby Computational Neuroscience Unit, 17 Queen Square, London WC1N 3AR, UK. Email: maneesh{at}gatsby.ucl.ac.uk

The relationship between a sound and its neural representation in the auditory cortex remains elusive. Simple measures such as the frequency response area or frequency tuning curve provide little insight into the function of the auditory cortex in complex sound environments. Spectrotemporal receptive field (STRF) models, despite their descriptive potential, perform poorly when used to predict auditory cortical responses, showing that nonlinear features of cortical response functions, which are not captured by STRFs, are functionally important. We introduce a new approach to the description of auditory cortical responses, using multilinear modeling methods. These descriptions simultaneously account for several nonlinearities in the stimulus–response functions of auditory cortical neurons, including adaptation, spectral interactions, and nonlinear sensitivity to sound level. The models reveal multiple inseparabilities in cortical processing of time lag, frequency, and sound level, and suggest functional mechanisms by which auditory cortical neurons are sensitive to stimulus context. By explicitly modeling these contextual influences, the models are able to predict auditory cortical responses more accurately than are STRF models. In addition, they can explain some forms of stimulus dependence in STRFs that were previously poorly understood.

Key words: neural coding; stimulus–response function; complex sounds; hearing; spectrotemporal receptive field; auditory cortex

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Received July 25, 2007; revised Nov. 16, 2007; accepted Dec. 15, 2007.

Correspondence should be addressed to Maneesh Sahani, Gatsby Computational Neuroscience Unit, 17 Queen Square, London WC1N 3AR, UK. Email: maneesh{at}gatsby.ucl.ac.uk

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