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The Journal of Neuroscience, January 7, 2009, 29(1):86-97; doi:10.1523/JNEUROSCI.4105-08.2009

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Development/Plasticity/Repair
Sensory Input Enhances Synaptogenesis of Adult-Born Neurons

Yoav Livneh,¹ Naomi Feinstein,¹ Marguerita Klein,³ and Adi Mizrahi^1,2

¹Department of Neurobiology, Institute for Life Sciences and ²The Interdisciplinary Center for Neural Computation, The Hebrew University of Jerusalem, Edmond J. Safra Campus, Givat Ram, Jerusalem 91904, Israel, and ³Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710

Correspondence should be addressed to Adi Mizrahi at the above address. Email: mizrahia{at}cc.huji.ac.il

The adult mammalian brain maintains a prominent stem cell niche in the subventricular zone supplying new neurons to the olfactory bulb. We examined the dynamics of synaptogenesis by imaging the formation and elimination of clusters of a postsynaptic marker (PSD95), genetically targeted to adult-born neurons. We imaged in vivo adult-born periglomerular neurons (PGNs) during two phases of development, immaturity and maturity. Immature PGNs showed high levels of PSD95 puncta dynamics during 12–72 h intervals. Mature PGNs were more stable compared with immature PGNs but still remained dynamic, suggesting that synaptogenesis persists long after these neurons integrated into the network. By combining intrinsic signal and two photon imaging we followed PSD95 puncta in sensory enriched glomeruli. Sensory input upregulated the development of adult-born PGNs only in enriched glomeruli. Our data provide evidence for an activity-based mechanism that enhances synaptogenesis of adult-born PGNs during their initial phases of development.

Key words: adult-neurogenesis; synaptogenesis; olfactory bulb; in vivo imaging; periglomerular; sensory enrichment

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Received Aug. 28, 2008; revised Nov. 4, 2008; accepted Nov. 25, 2008.

Correspondence should be addressed to Adi Mizrahi at the above address. Email: mizrahia{at}cc.huji.ac.il

This article has been cited by other articles:

				A. Mouret, G. Lepousez, J. Gras, M.-M. Gabellec, and P.-M. Lledo Turnover of Newborn Olfactory Bulb Neurons Optimizes Olfaction J. Neurosci., September 30, 2009; 29(39): 12302 - 12314. [Abstract] [Full Text] [PDF]

				W. Kelsch, C.-W. Lin, C. P. Mosley, and C. Lois A Critical Period for Activity-Dependent Synaptic Development during Olfactory Bulb Adult Neurogenesis J. Neurosci., September 23, 2009; 29(38): 11852 - 11858. [Abstract] [Full Text] [PDF]

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