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The Journal of Neuroscience, March 25, 2009, 29(12):3715-3719; doi:10.1523/JNEUROSCI.5457-08.2009

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Brief Communications
A Single Intra-PFC Infusion of BDNF Prevents Cocaine-Induced Alterations in Extracellular Glutamate within the Nucleus Accumbens

William J. Berglind, Timothy W. Whitfield Jr, Ryan T. LaLumiere, Peter W. Kalivas, and Jacqueline F. McGinty

Department of Neurosciences and Neurobiology of Addiction Research Center, Medical University of South Carolina, Charleston, South Carolina 29425

Correspondence should be addressed to Jacqueline F. McGinty, Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, MSC 510, Charleston, SC 29425. Email: mcginty{at}musc.edu

The glutamatergic pathway arising in the dorsomedial prefrontal cortex (dmPFC) and projecting to the nucleus accumbens (NAc) core is a critical component of the reward circuitry that underlies reinstatement to cocaine-seeking behavior. Brain-derived neurotrophic factor (BDNF) is expressed by and modulates PFC–NAc neurons. BDNF infusion into the dmPFC attenuates reinstatement to cocaine-seeking behavior, as well as some cocaine-induced molecular adaptations within the NAc. In the present study, it is demonstrated that a single intra-dmPFC infusion of BDNF prevents cocaine self-administration-induced reduction in basal extracellular glutamate, as well as cocaine prime-induced increases in extracellular glutamate levels within the NAc. These data suggest that intra-PFC BDNF attenuates reinstatement to cocaine-seeking behavior by normalizing cocaine-induced neuroadaptations that alter glutamate neurotransmission within the NAc.

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Received Nov. 12, 2008; revised Jan. 23, 2009; accepted Feb. 10, 2009.

Correspondence should be addressed to Jacqueline F. McGinty, Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, MSC 510, Charleston, SC 29425. Email: mcginty{at}musc.edu

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