QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, April 1, 2009, 29(13):4172-4188; doi:10.1523/JNEUROSCI.4956-08.2009

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Web of Science (2) Citing Articles via Google Scholar Google Scholar Articles by Snapyan, M. Articles by Saghatelyan, A. Search for Related Content PubMed PubMed Citation Articles by Snapyan, M. Articles by Saghatelyan, A. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CALCIUM COMPOUNDS CALCIUM, ELEMENTAL

 Previous Article  |  Next Article 

Cellular/Molecular
Vasculature Guides Migrating Neuronal Precursors in the Adult Mammalian Forebrain via Brain-Derived Neurotrophic Factor Signaling

Marina Snapyan,^1 * Morgane Lemasson,^1 * Monika S. Brill,^3,4 Mathieu Blais,⁵ Mireille Massouh,^1,2 Jovica Ninkovic,^3,4 Claude Gravel,^2,6 François Berthod,⁵ Magdalena Götz,^3,4 Philip A. Barker,⁷ André Parent,² and Armen Saghatelyan^1,6

¹The Cellular Neurobiology Unit and ²The Systemic Neurobiology Unit, Centre de Recherche Université Laval Robert-Giffard, Québec, Québec, Canada G1J 2G3, ³Department of Physiological Genomics, Institute of Physiology and Center for Integrated Protein Science Munich, Ludwig Maximilian University Munich, D-80336 Munich, Germany, ⁴Institute for Stem Cell Research, Helmholtz Zentrum München–National Research Center for Environmental Health, D-85764 Neuherberg/Munich, Germany, ⁵Laboratoire d'Organogénèse Expérimentale, Centre Hospitalier Affilié Universitaire de Québec, Département de Chirurgie, Université Laval, Hôpital du Saint-Sacrement, Québec, Canada G1S 4L8, ⁶Departement of Psychiatry, Université Laval, Québec, Québec, Canada G1K 7P4, and ⁷Montreal Neurological Institute, McGill University, Montreal, Québec, Canada H3A 2B4

Correspondence should be addressed to Armen Saghatelyan, Centre de Recherche Université Laval Robert-Giffard, Université Laval, 2601 Chemin de la Canardiere, Quebec, Quebec, Canada G1J 2G3. Email: armen.saghatelyan{at}crulrg.ulaval.ca

Adult neuronal precursors retain the remarkable capacity to migrate long distances from the posterior (subventricular zone) to the most anterior [olfactory bulb (OB)] parts of the brain. The knowledge about the mechanisms that keep neuronal precursors in the migratory stream and organize this long-distance migration is incomplete. Here we show that blood vessels precisely outline the migratory stream for new neurons in the adult mammalian forebrain. Real-time video imaging of cell migration in the acute slices demonstrate that neuronal precursors are retained in the migratory stream and guided into the OB by blood vessels that serve as a physical substrate for migrating neuroblasts. Our data suggest that endothelial cells of blood vessels synthesize brain-derived neurotrophic factor (BDNF) that fosters neuronal migration via p75NTR expressed on neuroblasts. Interestingly, GABA released from neuroblasts induces Ca²⁺-dependent insertion of high-affinity TrkB receptors on the plasma membrane of astrocytes that trap extracellular BDNF. We hypothesize that this renders BDNF unavailable for p75NTR-expressing migrating cells and leads to their entrance into the stationary period. Our findings provide new insights into the functional organization of substrates that facilitate the long-distance journey of adult neuronal precursors.

---

Received Oct. 14, 2008; revised Feb. 5, 2008; accepted Feb. 6, 2009.

Correspondence should be addressed to Armen Saghatelyan, Centre de Recherche Université Laval Robert-Giffard, Université Laval, 2601 Chemin de la Canardiere, Quebec, Quebec, Canada G1J 2G3. Email: armen.saghatelyan{at}crulrg.ulaval.ca

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help