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The Journal of Neuroscience, April 1, 2009, 29(13):4218-4227; doi:10.1523/JNEUROSCI.4225-08.2009

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Behavioral/Systems/Cognitive
MeCP2-Mediated Transcription Repression in the Basolateral Amygdala May Underlie Heightened Anxiety in a Mouse Model of Rett Syndrome

Megumi Adachi, Anita E. Autry, Herb E. Covington III, and Lisa M. Monteggia

Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9070

Correspondence should be addressed to Lisa M. Monteggia, Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9070. E-mail: Email: lisa.monteggia{at}utsouthwestern.edu

Rett syndrome (RTT) is an X-linked neurodevelopmental disorder that results from loss of function mutations in the methyl-CpG binding protein 2 (MECP2) gene. Using viral-mediated basolateral amygdala (BLA)-specific deletion of Mecp2 in mice, we show that intact Mecp2 function is required for normal anxiety behavior as well as some types of learning and memory. To examine whether these behavioral deficits are the result of impaired transcriptional repression, because Mecp2 is believed to act as a transcriptional repressor in complex with histone deacetylases (HDACs), we infused a HDAC inhibitor chronically into the BLA of wild-type mice. We found that HDAC inhibition produces behavioral deficits similar to those observed after the deletion of Mecp2 in the BLA. These results suggest a key role for Mecp2 as a transcriptional repressor in the BLA in mediating behavioral features of RTT.

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Received Sept. 2, 2008; revised Jan. 29, 2009; accepted Feb. 24, 2009.

Correspondence should be addressed to Lisa M. Monteggia, Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9070. E-mail: Email: lisa.monteggia{at}utsouthwestern.edu

This article has been cited by other articles:

				S. H. Wu and V. Camarena MeCP2 Function in the Basolateral Amygdala in Rett Syndrome J. Neurosci., August 12, 2009; 29(32): 9941 - 9942. [Full Text] [PDF]

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