QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, April 8, 2009, 29(14):4658-4663; doi:10.1523/JNEUROSCI.0493-09.2009

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Topolnik, L. Articles by Lacaille, J.-C. Search for Related Content PubMed PubMed Citation Articles by Topolnik, L. Articles by Lacaille, J.-C.

 Previous Article  |  Next Article 

Brief Communications
Activity-Dependent Compartmentalized Regulation of Dendritic Ca²⁺ Signaling in Hippocampal Interneurons

Lisa Topolnik,^1,2,3 Simon Chamberland,^1,3 Joe-Guillaume Pelletier,² Israeli Ran,² and Jean-Claude Lacaille²

¹Département de Biochimie et de Microbiologie, Faculté des Sciences et de Génie, Université Laval, Québec City, Québec, Canada G1V 0A6, ²Département de Physiologie, Groupe de Recherche sur le Système Nerveux Central, Université de Montréal, Montréal, Québec, Canada H3C 3J7, and ³Unite de Neurobiologie Cellulaire, Centre de Recherche Université Laval Robert-Giffard, Québec City, Québec, Canada G1J 2GS

Correspondence should be addressed to either of the following: Jean-Claude Lacaille, Département de Physiologie, Faculté de Médecine, Université de Montréal, Case Postale 6128, Succursale Centre-Ville, Montréal, Québec, Canada H3C 3J7, Email: jean-claude.lacaille{at}umontreal.ca; or Lisa Topolnik, Unite de Neurobiologie Cellulaire, CRULRG, 2601 Chemin de la Canardiere, Suite F-6530-2, Québec City, Québec, Canada G1J 2G3, Email: Lisa.Topolnik{at}crulrg.ulaval.ca

Activity-dependent regulation of synaptic inputs in neurons is controlled by highly compartmentalized and dynamic dendritic calcium signaling. Among multiple Ca²⁺ mechanisms operating in neuronal dendrites, voltage-sensitive Ca²⁺ channels (VSCCs) represent a major source of Ca²⁺ influx; however, their use-dependent implication, regulation, and function in different types of central neurons remain widely unknown. Using two-photon microscopy to probe Ca²⁺ signaling in dendrites of hippocampal oriens/alveus interneurons, we found that intense synaptic activity or local activation of mGluR5 induced long-lasting potentiation of action potential evoked Ca²⁺ transients. This potentiation of dendritic Ca²⁺ signaling required mGluR5-induced intracellular Ca²⁺ release and PKC activation and was expressed as a selective compartmentalized potentiation of L-type VSCCs. Thus, in addition to mGluR1a-dependent synaptic plasticity, hippocampal interneurons in the feedback inhibitory circuit demonstrate a novel form of mGluR5-induced dendritic plasticity. Given an implication of L-type VSCCs in the induction of Hebbian LTP at interneuron excitatory synapses, their activity-dependent regulation may represent a powerful mechanism for regulating synaptic plasticity.

---

Received Jan. 29, 2009; accepted March 9, 2009.

Correspondence should be addressed to either of the following: Jean-Claude Lacaille, Département de Physiologie, Faculté de Médecine, Université de Montréal, Case Postale 6128, Succursale Centre-Ville, Montréal, Québec, Canada H3C 3J7, Email: jean-claude.lacaille{at}umontreal.ca; or Lisa Topolnik, Unite de Neurobiologie Cellulaire, CRULRG, 2601 Chemin de la Canardiere, Suite F-6530-2, Québec City, Québec, Canada G1J 2G3, Email: Lisa.Topolnik{at}crulrg.ulaval.ca

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help