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The Journal of Neuroscience, April 29, 2009, 29(17):5483-5493; doi:10.1523/JNEUROSCI.4153-08.2009

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Behavioral/Systems/Cognitive
Stimulus-Specific Adaptation in the Inferior Colliculus of the Anesthetized Rat

Manuel S. Malmierca,^1,2 Salvatore Cristaudo,¹ David Pérez-González,^1,3 and Ellen Covey^1,3

¹Auditory Neurophysiology Unit, Institute of Neuroscience of Castilla y León, University of Salamanca, 37007 Salamanca, Spain, ²Department of Cell Biology and Pathology, Faculty of Medicine, University of Salamanca, 37007 Salamanca, Spain, and ³Department of Psychology, University of Washington, Seattle, Washington 98195

Correspondence should be addressed to Dr. Manuel S. Malmierca, Auditory Neurophysiology Unit, Institute of Neuroscience of Castilla y León, University of Salamanca. C/ Pintor Fernando Gallego, 1, 37007 Salamanca, Spain. Email: msm{at}usal.es

To identify sounds as novel, there must be some neural representation of commonly occurring sounds. Stimulus-specific adaptation (SSA) is a reduction in neural response to a repeated sound. Previous studies using an oddball stimulus paradigm have shown that SSA occurs at the cortex, but this study demonstrates that neurons in the inferior colliculus (IC) also show strong SSA using this paradigm. The majority (66%) of IC neurons showed some degree of SSA. Approximately 18% of neurons showed near-complete SSA. Neurons with SSA were found throughout the IC. Responses of IC neurons were reduced mainly during the onset component of the response, and latency was shorter in response to the oddball stimulus than to the standard. Neurons with near-complete SSA were broadly tuned to frequency, suggesting a high degree of convergence. Thus, some of the mechanisms that may underlie novelty detection and behavioral habituation to common sounds are already well developed at the midbrain.

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Received Aug. 25, 2008; revised Feb. 8, 2009; accepted Feb. 14, 2009.

Correspondence should be addressed to Dr. Manuel S. Malmierca, Auditory Neurophysiology Unit, Institute of Neuroscience of Castilla y León, University of Salamanca. C/ Pintor Fernando Gallego, 1, 37007 Salamanca, Spain. Email: msm{at}usal.es

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