QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, May 6, 2009, 29(18):5820-5831; doi:10.1523/JNEUROSCI.5703-08.2009

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ishikawa, M. Articles by Dong, Y. Search for Related Content PubMed PubMed Citation Articles by Ishikawa, M. Articles by Dong, Y. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB COCAINE

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Homeostatic Synapse-Driven Membrane Plasticity in Nucleus Accumbens Neurons

Masago Ishikawa,^1,2 Ping Mu,^1,2 Jason T. Moyer,⁴ John A. Wolf,⁵ Raymond M. Quock,³ Neal M. Davies,³ Xiu-ti Hu,⁶ Oliver M. Schlüter,⁷ and Yan Dong^1,2

¹Program in Neuroscience and Departments of ²Veterinary and Comparative Anatomy, Pharmacology, and Physiology and ³Pharmaceutical Sciences, Washington State University, Pullman, Washington 99164-6520, Departments of ⁴Bioengineering and ⁵Neuroscience, University of Pennsylvania, Philadelphia, Pennsylvania 19104, ⁶Department of Pharmacology, Rush University, Chicago, Illinois 60612, and ⁷Department of Molecular Neurobiology, European Neuroscience Institute, 37077 Göttingen, Germany

Correspondence should be addressed to Dr. Yan Dong or Dr. Oliver Schlüter, Wegner 205, PO Box 646520, Washington State University, Pullman, WA 99164-6520, Email: yan_dong{at}wsu.edu or Email: oschlue{at}gwdg.de

Stable brain function relies on homeostatic maintenance of the functional output of individual neurons. In general, neurons function by converting synaptic input to output as action potential firing. To determine homeostatic mechanisms that balance this input–output/synapse–membrane interaction, we focused on nucleus accumbens (NAc) neurons and demonstrated a novel form of synapse-to-membrane homeostatic regulation, homeostatic synapse-driven membrane plasticity (hSMP). Through hSMP, NAc neurons adjusted their membrane excitability to functionally compensate for basal shifts in excitatory synaptic input. Furthermore, hSMP was triggered by synaptic NMDA receptors (NMDARs) and expressed by the modification of SK-type Ca²⁺-activated potassium channels. Moreover, hSMP in NAc neurons was abolished in rats during a short- (2 d) or long- (21 d) term withdrawal from repeated intraperitoneal injections of cocaine (15 mg/kg/d, 5 d). These results suggest that hSMP is a novel form of synapse-to-membrane homeostatic plasticity and dysregulation of hSMP may contribute to cocaine-induced cellular alterations in the NAc.

---

Received Nov. 30, 2008; revised April 8, 2009; accepted April 8, 2009.

Correspondence should be addressed to Dr. Yan Dong or Dr. Oliver Schlüter, Wegner 205, PO Box 646520, Washington State University, Pullman, WA 99164-6520, Email: yan_dong{at}wsu.edu or Email: oschlue{at}gwdg.de

This article has been cited by other articles:

				S. Kourrich and M. J. Thomas Similar Neurons, Opposite Adaptations: Psychostimulant Experience Differentially Alters Firing Properties in Accumbens Core versus Shell J. Neurosci., September 30, 2009; 29(39): 12275 - 12283. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help