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The Journal of Neuroscience, May 6, 2009, 29(18):5897-5909; doi:10.1523/JNEUROSCI.0220-09.2009

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Behavioral/Systems/Cognitive
Functional Connectivity of the Macaque Brain across Stimulus and Arousal States

Sebastian Moeller,^1 * Nambi Nallasamy,^2 * Doris Y. Tsao,^1 * and Winrich A. Freiwald^1,3

¹Division of Biology, California Institute of Technology, Pasadena, California 91125, ²Harvard Medical School, Boston, Massachusetts 02115, and ³The Rockefeller University, New York, New York 10065

Correspondence should be addressed to Doris Y. Tsao, Broad Institute for Biological Sciences, Caltech, MC 114-96, Pasadena, CA 91125. Email: dortsao{at}caltech.edu

Cortical networks generate temporally correlated brain activity. To clarify the functional significance of this correlated activity, we asked whether and how its structure depends on stimulus and arousal state. Using independent components analysis of macaque functional magnetic resonance imaging data, we identified a large number of brain networks that were strikingly reproducible across different visual stimulus contexts. Fewer networks were reproducible across alert and anesthetized brain states. Network complexity ranged from bilateral single-node networks to networks comprising multiple discrete nodes distributed over 3 cm of cortex; one network identified in our survey included parts of the temporal parietal occipital junction, dorsal premotor cortex, insula, and posterior cingulate cortex bilaterally. Our results reveal the wealth of spatially structured correlated networks throughout the brain in both alert and anesthetized monkeys, and show that anesthesia significantly alters the spatial structure of these networks.

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Received Jan. 15, 2009; revised March 9, 2009; accepted March 25, 2009.

Correspondence should be addressed to Doris Y. Tsao, Broad Institute for Biological Sciences, Caltech, MC 114-96, Pasadena, CA 91125. Email: dortsao{at}caltech.edu

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