WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, May 27, 2009, 29(21):6989-7002; doi:10.1523/JNEUROSCI.1089-09.2009

This Article
Free Access Article
Right arrow Free Access Article Full Text
Right arrow Full Text (PDF)
Right arrow Supplemental Data
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Szabó, N.-E.
Right arrow Articles by Alvarez-Bolado, G.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Szabó, N.-E.
Right arrow Articles by Alvarez-Bolado, G.

 Previous Article  |  Next Article 

Development/Plasticity/Repair
Role of Neuroepithelial Sonic hedgehog in Hypothalamic Patterning

Nora-Emöke Szabó,1 Tianyu Zhao,1 Murat Çankaya,2 Thomas Theil,3 Xunlei Zhou,1 and Gonzalo Alvarez-Bolado1,4

1Department of Genes and Behavior, Max Planck Institute of Biophysical Chemistry, D-37077 Göttingen, Germany, 2Department of Chemistry, Faculty of Arts and Science, Atatürk University, 25240 Erzurum, Turkey, 3Centre for Neuroscience Research, University of Edinburgh, Edinburgh EH8 9XD, United Kingdom, and 4Department of Tissue Engineering and Experimental Embryology, University of Tübingen, D-72074 Tübingen, Germany

Correspondence should be addressed to Gonzalo Alvarez-Bolado, Department of Tissue Engineering and Experimental Embryology, Anatomisches Institut, Österbergstrasse 3, D-72074 Tübingen, Germany. Email: galvarez{at}anatom.uni-tuebingen.de

The hypothalamus is a region of the diencephalon with particularly complex patterning. Sonic hedgehog (Shh), encoding a protein with key developmental roles, shows a peculiar and dynamic diencephalic expression pattern. Here, we use transgenic strategies and in vitro experiments to test the hypothesis that Shh expressed in the diencephalic neuroepithelium (neural Shh) coordinates tissue growth and patterning in the hypothalamus. Our results show that neural Shh coordinates anteroposterior and dorsoventral patterning in the hypothalamus and in the diencephalon–telencephalon junction. Neural Shh also coordinates mediolateral hypothalamic patterning, since it is necessary for the lateral hypothalamus to attain proper size and is required for the specification of hypocretin/orexin cells. Finally, neural Shh is necessary to maintain expression of differentiation markers including survival factor Foxb1.

Received March 5, 2009; revised April 21, 2009; accepted April 23, 2009.

Correspondence should be addressed to Gonzalo Alvarez-Bolado, Department of Tissue Engineering and Experimental Embryology, Anatomisches Institut, Österbergstrasse 3, D-72074 Tübingen, Germany. Email: galvarez{at}anatom.uni-tuebingen.de






 -
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-