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The Journal of Neuroscience, June 24, 2009, 29(25):8166-8176; doi:10.1523/JNEUROSCI.0243-09.2009

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Behavioral/Systems/Cognitive
Functional Significance of Nonspatial Information in Monkey Lateral Intraparietal Area

Puiu F. Balan¹ and Jacqueline Gottlieb^1,2

¹Departments of Neuroscience and ²Psychiatry, Columbia University, New York, New York 10032

Correspondence should be addressed to Dr. Jacqueline Gottlieb, Department of Neuroscience, Columbia University, 1051 Riverside Drive, Kolb Research Annex, Room 569, New York, NY 10032. Email: jg2141{at}columbia.edu

Although the parietal cortex is traditionally associated with spatial perception and motor planning, recent evidence shows that neurons in the lateral intraparietal area (LIP) carry both spatial and nonspatial signals. The functional significance of the nonspatial information in the parietal cortex is not understood. To address this question, we tested the effect of unilateral reversible inactivation of LIP on three behavioral tasks known to evoke nonspatial responses. Each task included a spatial component (target selection in the hemifield contralateral or ipsilateral to the inactivation) and a nonspatial component, namely limb motor planning, the estimation of elapsed time, and reward-based decisions. Although inactivation reliably impaired performance on all tasks, the deficits were spatially specific (restricted to contralateral target locations), and there were no effects on nonspatial aspects on performance. This suggests that modulatory nonspatial signals in LIP represent feedback about computations performed elsewhere rather than a primary role of LIP in these computations.

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Received Jan. 15, 2009; revised April 22, 2009; accepted May 16, 2009.

Correspondence should be addressed to Dr. Jacqueline Gottlieb, Department of Neuroscience, Columbia University, 1051 Riverside Drive, Kolb Research Annex, Room 569, New York, NY 10032. Email: jg2141{at}columbia.edu

This article has been cited by other articles:

				C. J. Peck, D. C. Jangraw, M. Suzuki, R. Efem, and J. Gottlieb Reward Modulates Attention Independently of Action Value in Posterior Parietal Cortex J. Neurosci., September 9, 2009; 29(36): 11182 - 11191. [Abstract] [Full Text] [PDF]

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