WWW.JNEUROSCI.ORG
-
The Journal of Neuroscience
QUICK SEARCH:   [advanced]


     
-


HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP
The Journal of Neuroscience, July 22, 2009, 29(29):9219-9226; doi:10.1523/JNEUROSCI.5667-08.2009

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit an eLetter
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Barki-Harrington, L.
Right arrow Articles by Rosenblum, K.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Barki-Harrington, L.
Right arrow Articles by Rosenblum, K.

 Previous Article  |  Next Article 

Cellular/Molecular
Tyrosine Phosphorylation of the 2B Subunit of the NMDA Receptor Is Necessary for Taste Memory Formation

Liza Barki-Harrington, Alina Elkobi, Tali Tzabary, and Kobi Rosenblum

Department of Neurobiology and Ethology, Faculty of Sciences, University of Haifa, Haifa 31905, Israel

Correspondence should be addressed to Dr. Kobi Rosenblum, Department of Neurobiology and Ethology, Faculty of Sciences, University of Haifa, Mount Carmel, Haifa 31905, Israel. Email: kobir{at}psy.haifa.ac.il

We aimed to test whether tyrosine phosphorylation of the NMDA receptor (NMDAR) in the insular cortex is necessary for novel taste learning. We found that in rats, novel taste learning leads to elevated phosphorylation of tyrosine 1472 of the NR2B subunit of the NMDAR and increases the interaction of phosphorylated NR2B with the major postsynaptic scaffold protein PSD-95. Injection of the tyrosine kinase inhibitor genistein directly into the insular cortex of rats before novel taste exposure prevented the increase in NR2B tyrosine phosphorylation and behaviorally attenuated taste-memory formation. Functionally, tyrosine phosphorylation of NR2B after learning was found to determine the synaptic distribution of the NMDAR, since microinjection of genistein to the insular cortex altered the distribution pattern of NMDAR caused by novel taste learning.

Received Nov. 27, 2008; revised May 12, 2009; accepted May 19, 2009.

Correspondence should be addressed to Dr. Kobi Rosenblum, Department of Neurobiology and Ethology, Faculty of Sciences, University of Haifa, Mount Carmel, Haifa 31905, Israel. Email: kobir{at}psy.haifa.ac.il






 -
-

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help
-
Copyright 2009 by Society for Neuroscience ONLINE ISSN: 1529-2401
-