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The Journal of Neuroscience, July 22, 2009, 29(29):9380-9389; doi:10.1523/JNEUROSCI.0604-09.2009

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Development/Plasticity/Repair
The Embryonic Preoptic Area Is a Novel Source of Cortical GABAergic Interneurons

Diego M. Gelman,1 Francisco J. Martini,1 Sandrina Nóbrega-Pereira,1,2 Alessandra Pierani,3 Nicoletta Kessaris,4 and Oscar Marín1

1Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain, 2Doctoral Program in Experimental Biology and Biomedicine, Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal, 3Department de Biologie du Développement, Institut Jacques Monod, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 7592, Université Paris Diderot, 75251 Paris, France, and 4Wolfson Institute for Biomedical Research and Department of Cell and Developmental Biology, University College London, London WC1E 6AE, United Kingdom

Correspondence should be addressed to Dr. Oscar Marín at the above address. Email: o.marin{at}umh.es

GABA-containing (GABAergic) interneurons play an important role in the function of the cerebral cortex. Through mostly inhibitory mechanisms, interneurons control hyperexcitability and synchronize and shape the spatiotemporal dynamics of cortical activity underlying various brain functions. Studies over the past 10 years have demonstrated that, in most mammals, interneurons originate during development from the subcortical telencephalon—the subpallium—and reach the cerebral cortex through tangential migration. Until now, interneurons have been demonstrated to derive exclusively from two subpallial regions, the medial ganglionic eminence and the caudal ganglionic eminence. Here, we show that another subpallial structure, the preoptic area, is a novel source of cortical GABAergic interneurons in the mouse. In utero labeling and genetic lineage-tracing experiments demonstrate that neurons born in this region migrate to the neocortex and hippocampus, where they differentiate into a distinct population of GABAergic interneurons with relatively uniform neurochemical, morphological, and electrophysiological properties.

Received Feb. 5, 2009; revised June 3, 2009; accepted June 8, 2009.

Correspondence should be addressed to Dr. Oscar Marín at the above address. Email: o.marin{at}umh.es






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