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The Journal of Neuroscience, August 12, 2009, 29(32):10104-10110; doi:10.1523/JNEUROSCI.2087-09.2009

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Behavioral/Systems/Cognitive
Glycinergic Projection Neurons of the Cerebellum

Martha W. Bagnall,1,2 Brian Zingg,2 Alexandra Sakatos,2 Setareh H. Moghadam,2 Hanns Ulrich Zeilhofer,4,5 and Sascha du Lac1,2,3

1Neurosciences Graduate Program, University of California, San Diego, La Jolla, California 92093, 2Salk Institute for Biological Studies and 3Howard Hughes Medical Institute, La Jolla, California 92037, 4Institute of Pharmacology and Toxicology, University of Zurich, CH-8057 Zurich, Switzerland, and 5Institute of Pharmaceutical Sciences, Eidgenössische Technische Hochschule Zurich, CH-8093 Zurich, Switzerland

Correspondence should be addressed to Dr. Sascha du Lac, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037. Email: sascha{at}salk.edu

The cerebellum funnels its entire output through a small number of presumed glutamatergic premotor projection neurons in the deep cerebellar nuclei and GABAergic neurons that feed back to the inferior olive. Here we use transgenic mice selectively expressing green fluorescent protein in glycinergic neurons to demonstrate that many premotor output neurons in the medial cerebellar (fastigial) nuclei are in fact glycinergic, not glutamatergic as previously thought. These neurons exhibit similar firing properties as neighboring glutamatergic neurons and receive direct input from both Purkinje cells and excitatory fibers. Glycinergic fastigial neurons make functional projections to vestibular and reticular neurons in the ipsilateral brainstem, whereas their glutamatergic counterparts project contralaterally. Together, these data suggest that the cerebellum can influence motor outputs via two distinct and complementary pathways.

Received April 28, 2009; revised July 8, 2009; accepted July 11, 2009.

Correspondence should be addressed to Dr. Sascha du Lac, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037. Email: sascha{at}salk.edu






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