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The Journal of Neuroscience, August 12, 2009, 29(32):9961-9966; doi:10.1523/JNEUROSCI.0795-09.2009

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Brief Communications
Serotonin Transporter Availability in the Amygdala and Bed Nucleus of the Stria Terminalis Predicts Anxious Temperament and Brain Glucose Metabolic Activity

Jonathan A. Oler,1,4 Andrew S. Fox,2,5 Steven E. Shelton,1,4 Bradley T. Christian,1,3,5 Dhanabalan Murali,3,5 Terrence R. Oakes,5 Richard J. Davidson,1,2,4,5 and Ned H. Kalin1,2,4,5

Departments of 1Psychiatry, 2Psychology, and 3Medical Physics, 4HealthEmotions Research Institute, and 5Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin–Madison, Madison, Wisconsin 53719

Correspondence should be addressed to Dr. Ned H. Kalin, HealthEmotions Research Institute, Department of Psychiatry, University of Wisconsin–Madison, 6001 Research Park Boulevard, Madison, WI 53719. Email: nkalin{at}wisc.edu

The serotonin transporter (5-HTT) plays a critical role in regulating serotonergic neurotransmission and is implicated in the pathophysiology of anxiety and affective disorders. Positron emission tomography scans using [11C]DASB [11C]-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)-benzonitrile] to measure 5-HTT availability (an index of receptor density and binding) were performed in 34 rhesus monkeys in which the relationship between regional brain glucose metabolism and anxious temperament was previously established. 5-HTT availability in the amygdalohippocampal area and bed nucleus of the stria terminalis correlated positively with individual differences in a behavioral and neuroendocrine composite of anxious temperament. 5-HTT availability also correlated positively with stress-induced metabolic activity within these regions. Collectively, these findings suggest that serotonergic modulation of neuronal excitability in the neural circuitry associated with anxiety mediates the developmental risk for affect-related psychopathology.


Received Feb. 16, 2009; revised June 16, 2009; accepted July 6, 2009.

Correspondence should be addressed to Dr. Ned H. Kalin, HealthEmotions Research Institute, Department of Psychiatry, University of Wisconsin–Madison, 6001 Research Park Boulevard, Madison, WI 53719. Email: nkalin{at}wisc.edu






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