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The Journal of Neuroscience, August 19, 2009, 29(33):10254-10263; doi:10.1523/JNEUROSCI.1737-09.2009

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Behavioral/Systems/Cognitive
An Intersegmental Neuronal Architecture for Spinal Wave Propagation under Deletions

Toni Pérez,¹ Jesus A. Tapia,⁴ Claudio R. Mirasso,¹ Jordi García-Ojalvo,² Jorge Quevedo,³ Carlos A. Cuellar,⁴ and Elias Manjarrez⁴

¹Instituto de Física Interdisciplinar y Sistemas Complejos, Consejo Superior de Investigaciones Científicas-Universidad de las Islas Baleares, Campus Universitat de les Illes Balears, E-07122 Palma de Mallorca, Spain, ²Departament de Física i Enginyeria Nuclear, Universitat Politècnica de Catalunya, E-08222 Terrassa, Spain, ³Departamento de Fisiología, Biofísica y Neurociencias, Centro de Investigación y de Estudios Avanzados, CP 07360 Distrito Federal, Mexico, and ⁴Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, CP 72570 Puebla, Mexico

Correspondence should be addressed to Dr. Elias Manjarrez, Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 Sur 6301, Colonia San Manuel, CP 72570 Puebla, Mexico. E-mail: Email: eliasmanjarrez{at}gmail.com or Email: emanjar{at}siu.buap.mx

Recent studies have established and characterized the propagation of traveling electrical waves along the cat spinal cord during scratching, but the neuronal architecture that allows for the persistence of such waves even during periods of absence of bursts of motoneuron activity (deletions) is still unclear. Here we address this problem both theoretically and experimentally. Specifically, we monitored during long lasting periods of time the global electrical activity of spinal neurons during scratching. We found clear deletions of unaltered cycle in extensor activity without associated deletions of the traveling spinal wave. Furthermore, we also found deletions with a perturbed cycle associated with a concomitant absence of the traveling spinal wave. Numerical simulations of an asymmetric two-layer model of a central-pattern generator distributed longitudinally along the spinal cord qualitatively reproduce the sinusoidal traveling waves, and are able to replicate both classes of deletions. We believe these findings shed light into the longitudinal organization of the central-pattern generator networks in the spinal cord.

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Received April 10, 2009; revised July 9, 2009; accepted July 13, 2009.

Correspondence should be addressed to Dr. Elias Manjarrez, Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, 14 Sur 6301, Colonia San Manuel, CP 72570 Puebla, Mexico. E-mail: Email: eliasmanjarrez{at}gmail.com or Email: emanjar{at}siu.buap.mx

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