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The Journal of Neuroscience, August 26, 2009, 29(34):10600-10612; doi:10.1523/JNEUROSCI.2053-09.2009

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Behavioral/Systems/Cognitive
A Simple Model of Cortical Dynamics Explains Variability and State Dependence of Sensory Responses in Urethane-Anesthetized Auditory Cortex

Carina Curto, Shuzo Sakata, Stephan Marguet, Vladimir Itskov, and Kenneth D. Harris

Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102

Correspondence should be addressed to Kenneth D. Harris, Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102. Email: kdharris{at}rutgers.edu

The responses of neocortical cells to sensory stimuli are variable and state dependent. It has been hypothesized that intrinsic cortical dynamics play an important role in trial-to-trial variability; the precise nature of this dependence, however, is poorly understood. We show here that in auditory cortex of urethane-anesthetized rats, population responses to click stimuli can be quantitatively predicted on a trial-by-trial basis by a simple dynamical system model estimated from spontaneous activity immediately preceding stimulus presentation. Changes in cortical state correspond consistently to changes in model dynamics, reflecting a nonlinear, self-exciting system in synchronized states and an approximately linear system in desynchronized states. We propose that the complex and state-dependent pattern of trial-to-trial variability can be explained by a simple principle: sensory responses are shaped by the same intrinsic dynamics that govern ongoing spontaneous activity.

Received April 30, 2009; revised June 10, 2009; accepted July 1, 2009.

Correspondence should be addressed to Kenneth D. Harris, Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102. Email: kdharris{at}rutgers.edu






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