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The Journal of Neuroscience, September 9, 2009, 29(36):11153-11160; doi:10.1523/JNEUROSCI.5881-08.2009

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Cellular/Molecular
Non-Hebbian Synaptic Plasticity Induced by Repetitive Postsynaptic Action Potentials

Hiroyuki K. Kato,¹ Ayako M. Watabe,^1,2 and Toshiya Manabe^1,2

¹Division of Neuronal Network, Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, Tokyo 108-8639, Japan, and ²Core Research for Evolutional Science and Technology, Japan Science and Technology Agency, Kawaguchi 332-0012, Japan

Correspondence should be addressed to Dr. Toshiya Manabe at the above address. Email: tmanabe-tky{at}umin.ac.jp

Modern theories on memory storage have mainly focused on Hebbian long-term potentiation (LTP), which requires coincident activation of presynaptic and postsynaptic neurons for its induction. In addition to Hebbian LTP, the roles of non-Hebbian plasticity have also been predicted by some neuronal network models. However, still only a few pieces of evidence have been presented for the presence of such plasticity. In this study, we show in mouse hippocampal slices that LTP can be induced by postsynaptic repetitive depolarization alone in the absence of presynaptic inputs. The induction was dependent on voltage-dependent calcium channels instead of NMDA receptors (NMDARs), whereas the expression mechanism was shared with conventional NMDAR-dependent LTP. During the potentiation, the amplitude of spontaneous EPSCs was increased, suggesting a novel neuron-wide nature of this form of LTP. Furthermore, we also successfully induced LTP with trains of action potentials, which supported the possible existence of depolarizing pulse-induced LTP in vivo. Based on these findings, we suggest a model in which neuron-wide LTP works in concert with synapse-specific Hebbian plasticity to help information processing in memory formation.

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Received Dec. 11, 2008; revised July 23, 2009; accepted July 25, 2009.

Correspondence should be addressed to Dr. Toshiya Manabe at the above address. Email: tmanabe-tky{at}umin.ac.jp

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