QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

HOME  |   SEARCH  |   ARCHIVE  |   SUBSCRIBE  |   CONTACT  |   HELP

The Journal of Neuroscience, January 28, 2009, 29(4):1175-1190; doi:10.1523/JNEUROSCI.3328-08.2009

This Article Full Text Full Text (PDF) Supplemental Data Submit an eLetter Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (9) Citing Articles via Google Scholar Google Scholar Articles by Beckmann, M. Articles by Rushworth, M. F. S. Search for Related Content PubMed PubMed Citation Articles by Beckmann, M. Articles by Rushworth, M. F. S.

 Previous Article  |  Next Article 

Behavioral/Systems/Cognitive
Connectivity-Based Parcellation of Human Cingulate Cortex and Its Relation to Functional Specialization

Matthias Beckmann,^1,3 Heidi Johansen-Berg,¹ and Matthew F. S. Rushworth^1,2

¹Centre for Functional MRI of the Brain and ²Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, United Kingdom, and ³Universitätsklinikum "Carl Gustav Carus," Technische Universität Dresden, 01307 Dresden, Germany

Correspondence should be addressed to Matthew F. S. Rushworth, Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, UK. Email: matthew.rushworth{at}psy.ox.ac.uk

Whole-brain neuroimaging studies have demonstrated regional variations in function within human cingulate cortex. At the same time, regional variations in cingulate anatomical connections have been found in animal models. It has, however, been difficult to estimate the relationship between connectivity and function throughout the whole cingulate cortex within the human brain. In this study, magnetic resonance diffusion tractography was used to investigate cingulate probabilistic connectivity in the human brain with two approaches. First, an algorithm was used to search for regional variations in the probabilistic connectivity profiles of all cingulate cortex voxels with the whole of the rest of the brain. Nine subregions with distinctive connectivity profiles were identified. It was possible to characterize several distinct areas in the dorsal cingulate sulcal region. Several distinct regions were also found in subgenual and perigenual cortex. Second, the probabilities of connection between cingulate cortex and 11 predefined target regions of interest were calculated. Cingulate voxels with a high probability of connection with the different targets formed separate clusters within cingulate cortex. Distinct connectivity fingerprints characterized the likelihood of connections between the extracingulate target regions and the nine cingulate subregions. Last, a meta-analysis of 171 functional studies reporting cingulate activation was performed. Seven different cognitive conditions were selected and peak activation coordinates were plotted to create maps of functional localization within the cingulate cortex. Regional functional specialization was found to be related to regional differences in probabilistic anatomical connectivity.

Key words: cingulate cortex; DTI; tractography; human; premotor cortex; decision making; emotion

---

Received July 15, 2008; revised Nov. 13, 2008; accepted Dec. 2, 2008.

Correspondence should be addressed to Matthew F. S. Rushworth, Department of Experimental Psychology, University of Oxford, Oxford OX1 3UD, UK. Email: matthew.rushworth{at}psy.ox.ac.uk

This article has been cited by other articles:

				V. Venkatraman, A. G. Rosati, A. A. Taren, and S. A. Huettel Resolving Response, Decision, and Strategic Control: Evidence for a Functional Topography in Dorsomedial Prefrontal Cortex J. Neurosci., October 21, 2009; 29(42): 13158 - 13164. [Abstract] [Full Text] [PDF]

				B. B. Averbeck, A. Battaglia-Mayer, C. Guglielmo, and R. Caminiti Statistical Analysis of Parieto-Frontal Cognitive-Motor Networks J Neurophysiol, September 1, 2009; 102(3): 1911 - 1920. [Abstract] [Full Text] [PDF]

				I. Sarinopoulos, D. W. Grupe, K. L. Mackiewicz, J. D. Herrington, M. Lor, E. E. Steege, and J. B. Nitschke Uncertainty during Anticipation Modulates Neural Responses to Aversion in Human Insula and Amygdala Cereb Cortex, August 13, 2009; (2009) bhp155v1. [Abstract] [Full Text] [PDF]

				Y.-Y. Tang, Y. Ma, Y. Fan, H. Feng, J. Wang, S. Feng, Q. Lu, B. Hu, Y. Lin, J. Li, et al. Central and autonomic nervous system interaction is altered by short-term meditation PNAS, June 2, 2009; 106(22): 8865 - 8870. [Abstract] [Full Text] [PDF]

				The Neuroscientist Comments Neuroscientist, June 1, 2009; 15(3): 214 - 214. [PDF]

				T. E. J. Behrens, L. T. Hunt, and M. F. S. Rushworth The Computation of Social Behavior Science, May 29, 2009; 324(5931): 1160 - 1164. [Abstract] [Full Text] [PDF]

				J. P. Roiser, B. de Martino, G. C. Y. Tan, D. Kumaran, B. Seymour, N. W. Wood, and R. J. Dolan A Genetically Mediated Bias in Decision Making Driven by Failure of Amygdala Control J. Neurosci., May 6, 2009; 29(18): 5985 - 5991. [Abstract] [Full Text] [PDF]

				P. L. Croxson, M. E. Walton, J. X. O'Reilly, T. E. J. Behrens, and M. F. S. Rushworth Effort-Based Cost-Benefit Valuation and the Human Brain J. Neurosci., April 8, 2009; 29(14): 4531 - 4541. [Abstract] [Full Text] [PDF]

Home  |   Search  |   Archive  |   Subscribe  |   Contact  |   Help