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The Journal of Neuroscience, October 7, 2009, 29(40):12506-12520; doi:10.1523/JNEUROSCI.2003-09.2009

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Development/Plasticity/Repair
Sonic Hedgehog Regulates Integrin Activity, Cadherin Contacts, and Cell Polarity to Orchestrate Neural Tube Morphogenesis

Claire Fournier-Thibault,1,2 Cédrine Blavet,1,2 Artem Jarov,1,2 Fernanda Bajanca,3,4 Sólveig Thorsteinsdóttir,3,4 and Jean-Loup Duband1,2

1Université Pierre et Marie Curie–Paris 6, Laboratoire de Biologie du Développement, and 2Centre National de la Recherche Scientifique, Laboratoire de Biologie du Développement, 75005 Paris, France, 3Departamento de Biologia Animal, Centro de Biologia Ambiental, Faculdade de Ciências, Universidade de Lisboa, 1749-016 Lisboa, Portugal, and 4Instituto Gulbenkian de Ciência, 2781-901 Oeiras, Portugal

Correspondence should be addressed to either Claire Fournier-Thibault or Jean-Loup Duband, Université Pierre et Marie Curie–Paris 6, Centre National de la Recherche Scientifique, Laboratoire de Biologie du Développement, 75005 Paris, France. Email: cfournie{at}snv.jussieu.fr or Email: jean-loup.duband{at}upmc.fr

In vertebrates, the embryonic nervous system is shaped and patterned by a series of temporally and spatially regulated cell divisions, cell specifications, and cell adhesions and movements. Morphogens of the Hedgehog, Wnt, and bone morphogenetic protein families have been shown to play a crucial role in the control of cell division and specification in the trunk neural tube, but their possible implication in the regulation of adhesive events has been poorly documented. In the present study, we demonstrate that Sonic hedgehog regulates neural epithelial cell adhesion and polarity through regulation of integrin activity, cadherin cell–cell contact, and cell polarity genes in immature neural epithelial cells before the specification of neuronal cells. We propose that Sonic hedgehog orchestrates neural tube morphogenesis by coordinating adhesive and motility events with cell proliferation and differentiation.

Received April 28, 2009; revised July 17, 2009; accepted Aug. 1, 2009.

Correspondence should be addressed to either Claire Fournier-Thibault or Jean-Loup Duband, Université Pierre et Marie Curie–Paris 6, Centre National de la Recherche Scientifique, Laboratoire de Biologie du Développement, 75005 Paris, France. Email: cfournie{at}snv.jussieu.fr or Email: jean-loup.duband{at}upmc.fr






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