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The Journal of Neuroscience, October 7, 2009, 29(40):12521-12531; doi:10.1523/JNEUROSCI.0640-09.2009

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Behavioral/Systems/Cognitive
Gamma-Band Synchronization in the Macaque Hippocampus and Memory Formation

Michael J. Jutras,1,2 Pascal Fries,4,5 and Elizabeth A. Buffalo1,2,3

1Yerkes National Primate Research Center, 2Neuroscience Program, Emory University, and 3Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30329, 4Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, 6525 EN Nijmegen, The Netherlands, and 5Ernst Strüngmann Institute in Cooperation with Max Planck Society, 60528 Frankfurt, Germany

Correspondence should be addressed to Elizabeth A. Buffalo, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329. Email: elizabeth.buffalo{at}emory.edu

Increasing evidence suggests that neuronal synchronization in the gamma band (30–100 Hz) may play an important role in mediating cognitive processes. Gamma-band synchronization provides for the optimal temporal relationship between two signals to produce the long-term synaptic changes that have been theorized to underlie memory formation. Although neuronal populations in the hippocampus oscillate in the gamma range, the role of these oscillations in memory formation is still unclear. To address this issue, we recorded neuronal activity in the hippocampus while macaque monkeys performed a visual recognition memory task. During the encoding phase of this task, hippocampal neurons displayed gamma-band synchronization. Additionally, enhanced gamma-band synchronization during encoding predicted greater subsequent recognition memory performance. These changes in synchronization reflect enhanced coordination among hippocampal neurons and may facilitate synaptic changes necessary for successful memory encoding.

Received Feb. 6, 2009; revised Aug. 31, 2009; accepted Sept. 2, 2009.

Correspondence should be addressed to Elizabeth A. Buffalo, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329. Email: elizabeth.buffalo{at}emory.edu






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