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The Journal of Neuroscience, October 14, 2009, 29(41):12764-12767; doi:10.1523/JNEUROSCI.3566-09.2009

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Symposia and Mini-Symposia
New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function

Michael E. Greenberg,1 Baoji Xu,2 Bai Lu,3 and Barbara L. Hempstead4

1Harvard Medical School, Boston, Massachusetts 02115, 2Georgetown University, Washington, DC 20057, 3National Institute of Child Health and Development, National Institutes of Health, Bethesda, Maryland 20847, and 4Weill Cornell Medical College, New York, New York 10065

Correspondence should be addressed to Barbara L. Hempstead at the above address. Email: blhempst{at}med.cornell.edu

BDNF has pleiotropic effects on neuronal development and synaptic plasticity that underlie circuit formation and cognitive function. Recent breakthroughs reveal that neuronal activity regulates BDNF cell biology, including Bdnf transcription, dendritic targeting and trafficking of BDNF mRNA and protein, and secretion and extracellular conversion of proBDNF to mature BDNF. Defects in these mechanisms contribute differentially to cognitive dysfunction and anxiety-like behaviors. Here we review recent studies, presented at a symposium at Neuroscience 2009, that describe regulatory mechanisms that permit rapid and dynamic refinement of BDNF actions in neurons.

Received July 15, 2009; revised Aug. 14, 2009; accepted Aug. 21, 2009.

Correspondence should be addressed to Barbara L. Hempstead at the above address. Email: blhempst{at}med.cornell.edu






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