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The Journal of Neuroscience, October 14, 2009, 29(41):12795-12801; doi:10.1523/JNEUROSCI.3520-09.2009

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Symposia and Mini-Symposia
Nutrition, Brain Aging, and Neurodegeneration

James Joseph,¹ Greg Cole,² Elizabeth Head,³ and Donald Ingram⁴

¹USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, ²Geriatric Research, Education and Clinical Centers, Veterans Affairs Medical Center, and Department of Medicine, University of California, Los Angeles, Sepulveda, California 91343, ³University of Kentucky Sanders-Brown Center on Aging, Lexington, Kentucky 40536, and ⁴Pennington Biomedical Center, Baton Rouge, Louisiana 70808

Correspondence should be addressed to Dr. James Joseph, USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111. Email: james.joseph{at}tufts.edu

The onset of age-related neurodegenerative diseases superimposed on a declining nervous system could enhance the motor and cognitive behavioral deficits that normally occur in senescence. It is likely that, in cases of severe deficits in memory or motor function, hospitalization and/or custodial care would be a likely outcome. This means that unless some way is found to reduce these age-related decrements in neuronal function, health care costs will continue to rise exponentially. Applying molecular biological approaches to slow aging in the human condition may be years away. So, it is important to determine what methods can be used today to increase healthy aging, forestall the onset of these diseases, and create conditions favorable to obtaining a "longevity dividend" in both financial and human terms. Recent studies suggest that consumption of diets rich in antioxidants and anti-inflammatory components such as those found in fruits, nuts, vegetables, and spices, or even reduced caloric intake, may lower age-related cognitive declines and the risk of developing neurodegenerative disease.

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Received July 21, 2009; revised July 28, 2009; accepted Aug. 4, 2009.

Correspondence should be addressed to Dr. James Joseph, USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111. Email: james.joseph{at}tufts.edu

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