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The Journal of Neuroscience, October 21, 2009, 29(42):13158-13164; doi:10.1523/JNEUROSCI.2708-09.2009

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Behavioral/Systems/Cognitive
Resolving Response, Decision, and Strategic Control: Evidence for a Functional Topography in Dorsomedial Prefrontal Cortex

Vinod Venkatraman,^1,2,3 Alexandra G. Rosati,² Adrienne A. Taren,² and Scott A. Huettel^1,2,3

¹Brain Imaging and Analysis Center, Durham, North Carolina 27710, and ²Center for Cognitive Neuroscience and ³Department of Psychology and Neuroscience, Duke University, Durham, North Carolina 27710

Correspondence should be addressed to Scott A. Huettel, Center for Cognitive Neuroscience, Box 90999, Duke University, Durham, NC 27710. Email: scott.huettel{at}duke.edu

The dorsomedial prefrontal cortex (DMPFC) plays a central role in aspects of cognitive control and decision making. Here, we provide evidence for an anterior-to-posterior topography within the DMPFC using tasks that evoke three distinct forms of control demands—response, decision, and strategic—each of which could be mapped onto independent behavioral data. Specifically, we identify three spatially distinct regions within the DMPFC: a posterior region associated with control demands evoked by multiple incompatible responses, a middle region associated with control demands evoked by the relative desirability of decision options, and an anterior region that predicts control demands related to deviations from an individual's preferred decision-making strategy. These results provide new insight into the functional organization of DMPFC and suggest how recent controversies about its role in complex decision making and response mapping can be reconciled.

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Received June 9, 2009; revised Aug. 2, 2009; accepted Sept. 15, 2009.

Correspondence should be addressed to Scott A. Huettel, Center for Cognitive Neuroscience, Box 90999, Duke University, Durham, NC 27710. Email: scott.huettel{at}duke.edu

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