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The Journal of Neuroscience, October 28, 2009, 29(43):13613-13620; doi:10.1523/JNEUROSCI.2041-09.2009

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Behavioral/Systems/Cognitive
Broadband Shifts in Local Field Potential Power Spectra Are Correlated with Single-Neuron Spiking in Humans

Jeremy R. Manning,¹ Joshua Jacobs,² Itzhak Fried,^3,4,5,6 and Michael J. Kahana²

¹Neuroscience Graduate Group and ²Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, ³Division of Neurosurgery and ⁴Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, California 90095, and ⁵Functional Neurosurgery Unit, Tel-Aviv Medical Center, and ⁶Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel

Correspondence should be addressed to Michael J. Kahana, Department of Psychology, University of Pennsylvania, 3401 Walnut Street, Room 303C, Philadelphia, PA 19104. Email: kahana{at}psych.upenn.edu

A fundamental question in neuroscience concerns the relation between the spiking of individual neurons and the aggregate electrical activity of neuronal ensembles as seen in local field potentials (LFPs). Because LFPs reflect both spiking activity and subthreshold events, this question is not simply one of data aggregation. Recording from 20 neurosurgical patients, we directly examined the relation between LFPs and neuronal spiking. Examining 2030 neurons in widespread brain regions, we found that firing rates were positively correlated with broadband (2–150 Hz) shifts in the LFP power spectrum. In contrast, narrowband oscillations correlated both positively and negatively with firing rates at different recording sites. Broadband power shifts were a more reliable predictor of neuronal spiking than narrowband power shifts. These findings suggest that broadband LFP power provides valuable information concerning neuronal activity beyond that contained in narrowband oscillations.

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Received April 21, 2009; revised Sept. 24, 2009; accepted Sept. 28, 2009.

Correspondence should be addressed to Michael J. Kahana, Department of Psychology, University of Pennsylvania, 3401 Walnut Street, Room 303C, Philadelphia, PA 19104. Email: kahana{at}psych.upenn.edu

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